A human KLOTHO KL-VS variant associates with preserved executive function in PD, and elevating klotho in α-synuclein mouse and cellular models improves cognition and synaptic plasticity, lowers α-synuclein levels, rescues NMDAR (GluN2B)-dependent signaling, and enhances microglial uptake of…

This medicinal chemistry study reports RBG derivatives and identifies compound 2-5c as a more potent Nrf2 activator (EC50 4.18 µM) that is neuroprotective in MPP+-treated BV2 cells and rescues motor deficits in MPTP mice.

This study shows paraquat induces microglia-driven neuroinflammation that drives pro-inflammatory astrocyte polarization and dopaminergic neuron loss, effects that are reversed by microglial depletion or activation of the PI3K/AKT pathway.

Intranasal curcumin reduced anxio-depressive behaviors, oxidative stress, and downregulated NF-κB/NLRP3 inflammasome signaling in a rotenone-induced rat model of Parkinson's disease.

Using an MPTP mouse model, diffusion kurtosis imaging and 1H-MRS identified region-specific increases in diffusivity and alterations in Glu/Gln/NAA/Tau ratios that correlated with neuronal loss, gliosis, and dopaminergic degeneration at 24–72 hours post-treatment.

Large observational study of 2,116 Italian PD patients found overall BMI similar to the general population but with sex-specific differences: women had lower BMI, received higher levodopa dosage per kg, and exhibited more dyskinesia, and BMI correlated with levodopa dose and complications.

This FDG- and DAT-PET study in 270 MSA patients identifies distinct metabolic patterns for MSA-P (hypermetabolism in pons/cerebellar posterior lobe/pallidum and hypometabolism in putamen/parieto‑occipital areas) and MSA-C (cerebellar and putaminal hypometabolism), shows greater striatal DAT loss in…

A pilot randomized single-center trial (n=80) found that a nurse-led, Theory of Symptom Management–based home program reduced sialorrhea severity and improved self-management in Parkinson's patients after four weeks compared with control.

Large UK primary-care cohort (2007–2021) found declining age-standardized PD incidence but rising PD prevalence, increased vascular parkinsonism diagnoses since 2010, and stable drug-induced parkinsonism, with rates rising with age and generally higher in males.

Randomized controlled trial protocol testing a 3-week cane-training program versus a time/attention-controlled stretching and education program to evaluate effects on gait speed, mobility, freezing, falls-related outcomes, and satisfaction in people with Parkinson’s disease.

Large multi-centre analyses of 11,243 individuals show that social apathy is a coherent and separable symptom dimension across health, psychiatric, and neurocognitive disorders, including Parkinson's disease.

Engineered exosomes (NEXOGFLG-P1) carrying a GRP94-targeting ligand and a cathepsin-B-cleavable autophagy-targeting peptide cross the BBB, home to substantia nigra neurons in MPTP mice, release the degrader intracellularly, and reduce α-synuclein aggregates via autophagy-lysosomal degradation.

In A53T/PFF mice, sleep deprivation selectively upregulates astrocytic LAG3, which disrupts AQP4 polarization and glymphatic α-synuclein clearance to worsen motor deficits and neurodegeneration, and astrocyte-specific AAV-mediated LAG3 knockdown restores clearance and attenuates pathology.

The paper identifies IRF7 as a mitochondria-related gene upregulated in Parkinson's disease that correlates with ferroptosis and immune changes, is downregulated by physical exercise, and in vitro modulates lipid ROS, ATP, mitochondrial morphology, and ferroptosis-related genes.

In a biomarker-defined cohort of PSG-confirmed iRBD participants positive for CSF α-synuclein seed amplification, investigators observed multi-domain prodromal Lewy body disease features (cognitive deficits, subthreshold parkinsonism, neuropsychiatric, autonomic, and sensory symptoms) at…

In patients with isolated REM sleep behavior disorder, higher DTI-ALPS indices—indicative of better glymphatic function—were associated with longer prodromal symptom duration and substantially delayed phenoconversion to alpha-synucleinopathy.

Wearable inertial-sensor gait measures in idiopathic RBD patients—particularly stride length, swing time variability, and arm-swing metrics—were associated with later phenoconversion and preferentially predicted a parkinsonism-first trajectory, with converters showing steeper longitudinal decline…

This study reports that plasma neurofilament light chain is elevated in isolated REM sleep behavior disorder, correlates with neurogenic orthostatic hypotension, and may mark an autonomic-severe iRBD subgroup with greater risk of phenoconversion (notably to MSA).

This PSG study found that PD patients with levodopa-induced dyskinesia lack the normal overnight increase in cortical sample entropy during N3 sleep observed in controls, and that reduced overnight SampEn change correlates with dyskinesia severity.

A critical review summarizing the history, current status, and misconceptions of dopamine cell replacement therapy for Parkinson’s disease, from fetal grafts to stem cell-derived vmDA neuron transplants now entering clinical trials.

Narrative review synthesizing preclinical (mostly rodent) evidence that exercise-released exerkines—including BDNF, irisin, cathepsin B, IL-6, and IGF-1—modulate neurogenesis, synaptic plasticity and neuroinflammation and could underlie exercise’s benefits in neurodegenerative and mental disorders.

Clinical guideline addressing diagnosis and outpatient management of dysphagia in Parkinson's disease, recommending targeted history, FEES, and individualized multidisciplinary treatment (speech therapy, physiotherapy, occupational and respiratory therapy, nutritional support).

This review synthesizes evidence that dysfunctional Ca2+-storing organelles (endoplasmic reticulum, mitochondria, lysosomes) and their interconnections drive neurodegeneration and highlights specific interventions—modulating mitochondrial Ca2+ handling at mitochondria-associated membranes/MCU,…

Using genome-scale metabolic models and the TAMBOOR algorithm, the study predicts patient-specific metabolite secretion changes in Parkinson’s disease, identifies consensus and cluster-specific biomarkers (including dopamine, salsolinol, vitamin D3, retinal, melatonin, biliverdin), and stratifies…

In LPS/TNF-α-induced mouse and SH-SY5Y cell PD models, biochanin A reduced lipid peroxidation, improved iron and antioxidant balance, and rescued behavioral and cellular deficits by inhibiting ferroptosis via the Sirt1/Nrf2/GPX4 signaling axis, with pathway involvement probed using ML385 and EX527.