Quantitative ultrasound radiofrequency Nakagami imaging detected increased muscle scattering (higher m parameter) across multiple muscles in Parkinson's patients versus controls, with the gastrocnemius medialis m strongly correlating with disease severity and good diagnostic performance in a small…

The paper presents a robust rank-based longitudinal global percentile outcome and associated regression/estimation methods (including dropout handling and variance estimation) to integrate multiple time-varying endpoints and applies it to a Parkinson’s disease clinical trial.

Developed a task-specific machine learning system with wearable sensors to automatically score multi-limb bradykinesia (MDS‑UPDRS III tasks) showing promising accuracy (peak F1≈0.87) in a small cohort (21 PD, 8 controls).

Prospective study of 10 advanced unilateral tremor-rigid PD patients treated with stereotactic radiofrequency ablation of the caudal zona incerta and Fields of Forel showed very large, sustained UPDRS III improvements over 3 years with minimal transient adverse effects.

Sensor-equipped insoles measuring plantar pressure detect subtle and dual-task-specific gait abnormalities in early-stage Parkinson's disease that conventional spatiotemporal metrics largely miss.

Graph-theory analysis of inter-muscular coherence from instrumented gait EMG shows PD patients have increased muscle network density and reduced modularity versus controls, which move toward normal levels 12 months after bilateral subthalamic DBS and correlate with UPDRS-III improvement.

A focused review examining how chaperones (Hsp90, Hsp110, Hsp27, and DJ-1) regulate proteostasis and how their dysfunction may contribute to neurodegenerative diseases including Parkinson's, with discussion of mechanisms for folding, aggregation prevention, and degradation pathways.

Using in vivo negligible-depletion SPME in a 6‑OHDA rat model, the study quantified free and total anandamide (AEA) and 2‑AG, finding significantly elevated striatal free AEA in lesioned animals while 2‑AG was undetectable in vivo.

This study reports that Huntington's disease patients exhibit dual pallidal oscillatory signatures—posterior GP theta (2–8 Hz) linked to hyperkinesia and high beta (20–30 Hz) linked to hypokinesia—mapped to distinct pallidal subregions and indirect/direct pathway connectivity and proposed as…

Longitudinal analysis in PPMI shows accelerated epigenetic aging in blood associates with worsening tremor phenotypes in Parkinson's disease—particularly in men—while associations with gait, rigidity, and bradykinesia are weaker or absent.

A computational mean firing-rate model incorporating cortex, thalamus and PPN identifies how dopaminergic parameter interactions, synaptic weights, delays and time constants can produce pathological beta-band oscillations in basal ganglia circuits.

Resting-state EEG microstate transition patterns (reduced D→B and increased E→F and F→C) differentiate PD patients with visual hallucinations with ~89.5% accuracy.

Using 3D motion capture, force plates, and EMG from 106 participants performing a sit-to-walk task, the authors identified three biomechanical features (mean COM speed, anteroposterior CoP–COM displacement during gait-initiation, and forward thoracic range of motion) and trained a random forest…

A 6-month prospective, open-label US observational study found add-on opicapone improved motor and non-motor fluctuations and was generally well tolerated in Parkinson's patients with OFF episodes.

In a retrospective longitudinal cohort, Parkinson's patients with baseline neurogenic orthostatic hypotension experienced significantly faster decline in global and multiple domain-specific cognitive scores (MoCA) over time, without accelerated motor or nonmotor symptom progression.

This study shows PD patients with depression exhibit pronounced oculomotor impairments—longer initiation times, slower smooth pursuit, and reduced saccade velocities—with average saccade velocity predicting depression (AUC 0.919) and negatively correlating with HAMD scores.

This study reports that bilingual early-stage idiopathic Parkinson's patients exhibit microstructural language deficits (lower MLU-M, more morphological errors and verbal fragmentation), pragmatic changes (fewer enrichment expressions, more exclamations), and altered prosody, with bilingualism…

This prospective cohort study found that total electrical energy delivered (TEED) and programming parameters after subthalamic nucleus DBS differ by Parkinson's motor subtype, with tremor-dominant patients requiring the highest stimulation energy, followed by PIGD and mixed subtypes.

Single-case report linking a heterozygous truncating CACNA1C variant to adult-onset combined dystonia–parkinsonism with improvement after GPi-DBS.

Individual-patient meta-analysis of six European population-based PD incidence cohorts (n=883) reports median survival of 9.4 years, median time to postural instability/functional dependency ~7.4 years, ~50% dementia by 10 years, and identifies older age, higher MDS-UPDRS-III, lower MMSE, GBA…

In a small observational secondary analysis of PKG wearable data (n=25–30 complete cases), increased percent time in dyskinesia tended to associate with less improvement in total MDS‑UPDRS over routine treat‑to‑target care, but the adjusted effect was borderline (β=0.25 per 1% PTD, p=0.064) and…

The authors developed an anthracene-functionalized MCM-41 nanoparticle fluorescence sensor array to detect ATP and used pattern-recognition (LDA, ANN) on saliva samples to discriminate Parkinson's disease patients from controls (n=24 vs 23) with 73.7% sensitivity and 83.3% specificity.

In a 4-year prospective cohort of 93 patients with multiple system atrophy, higher baseline plasma neurofilament light chain (NfL) predicted faster motor decline, earlier attainment of disability milestones and increased mortality, whereas longitudinal NfL levels declined in mid-to-late disease and…

In a 5-year longitudinal analysis of prodromal PD participants from PPMI (61 with complete follow-up), lower baseline serum uric acid independently predicted incident depression (HR=0.776) after adjustment, alongside higher MDS‑UPDRS I scores.

In a 12‑week randomized, double‑blind, placebo‑controlled trial of a nine‑strain probiotic in 61 people with PD and clinically significant anxiety, the probiotic did not reduce anxiety versus placebo, produced no detectable changes in gut microbiota composition or systemic inflammatory markers, but…