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RESEARCH PAPER

Erratum for the Research Article "Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B" by P. Pal et al.

PMID

41894517

Journal

Science advances

Publication Date

2026-03-27

Grade

AI Summary

This is an erratum for a study reporting that the Parkinson's-linked VPS35[D620N] mutation drives LRRK2-dependent lysosomal recruitment of RILPL1 and TMEM55B.

Why It Matters

While the erratum itself adds no new data, the corrected study ties retromer (VPS35) dysfunction to LRRK2-regulated lysosomal processes—mechanistically relevant to LRRK2-targeted therapies and lysosome/retromer-focused approaches in PD.

Abstract

Score Breakdown

AI Score

12.0

Base Score

14.9

Rank Score

15.7

Narrative Velocity

AI Confidence

NEUROCOMPUTE VISUAL SYSTEM