A narrative review summarizing epidemiology, classification, proposed pathophysiology, and clinical management of headaches in Parkinson's disease, noting prevalence (up to ~49%), types (tension-type, migraine), links to motor fluctuations and dopaminergic therapy, and evidence from cohorts and…

Although it does not advance core molecular targets for disease-modification, the paper highlights an underrecognized non-motor phenotype and mechanistic themes (nociceptive and neuroplastic pain, therapy-related effects) that can inform symptomatic management, patient stratification, and ancillary…

Headaches are common but underrecognized non-motor symptoms in Parkinson's disease (PD). They may appear as primary headaches, secondary headaches or as a part of PD-related nociceptive and neuroplastic pain syndromes. The prevalence of headaches in PD varies widely, with observational studies suggesting that up to 49% of patients report headaches, including tension-type headaches (TTH) and migraines. Headaches related to PD may present prodromally, occur during motor fluctuations or as a side effect of dopaminergic therapy. This review summarizes the epidemiology, classification, pathophysiology and clinical management of headaches in PD, with an emphasis on evidence from population-based cohort studies, imaging research, and clinical observations.