This review describes virtual reality's growing use across medicine and notes some beneficial but methodologically limited evidence for motor rehabilitation and symptom management in Parkinson's disease.

VR is valuable for symptomatic rehabilitation, objective outcome measurement, and potential digital biomarkers in PD trials, but it offers minimal actionable molecular or target-based insights for Parkinson's therapeutic discovery.

Virtual reality has rapidly established itself in recent years as an innovative component of modern medicine. It is applied in rehabilitation, neurology, oncology, psychotherapy, geriatric care, and many other areas of clinical practice. Advanced systems make it possible to create individualized, controlled, and interactive environments for training motor, cognitive, and behavioral functions, while providing immediate feedback and objective measurement of patient performance. The technology is used not only in therapy, but also in healthcare education, surgical simulation, and crisis-scenario training. Clinical studies and meta-analyses demonstrate beneficial effects of virtual reality on anxiety, depression, motor rehabilitation after stroke, Parkinson's disease, and postural stability in older adults. Despite these promising results, significant limitations remain, including methodological shortcomings of existing studies, technical and organizational barriers, the risk of cybersickness, and the need for protocol standardization. Projects in the Czech Republic illustrate the practical application of virtual reality; however, fully unlocking its potential will require ongoing research and long-term monitoring to objectively evaluate its effectiveness, safety, and sustainability.