Case report where delayed [18F]FP-CIT PET/CT showed cortical tracer uptake corresponding to renal cell carcinoma brain metastases (and a striatal photopenic area from chronic infarct), indicating that hypervascular metastases can cause nonspecific cortical retention likely from altered…

Minimal direct value for Parkinson's therapeutic discovery, but important for clinical and research neuroimaging: it cautions that atypical cortical DAT-ligand uptake can reflect metastases or perfusion/BBB effects rather than synucleinopathy, which can prevent misdiagnosis and confounding in…

A 77-year-old man with a remote history of renal cell carcinoma (RCC) presented with gait disturbance and underwent delayed [18F]FP-CIT PET/CT to evaluate Parkinsonism. The scan showed focal uptake in the temporoparietal and insular cortices with a focal striatal photopenic defect. Brain MRI confirmed enhancing metastases corresponding to the cortical foci and attributed the striatal abnormality to chronic infarction. Hypervascular metastases such as RCC may exhibit cortical [18F]FP-CIT uptake, possibly from increased perfusion and/or altered blood-brain barrier permeability, reflecting nonspecific tracer retention. Therefore, cortical uptake warrants cautious interpretation and appropriate correlation with clinical history and anatomic imaging for differential diagnosis.