This paper reports generation and characterization of three donor-matched iPSC lines derived from postmortem dura fibroblasts from individuals with neuropathologically confirmed AD, PD, and PART, retaining donor genomic identity for use in disease modeling.

These well-characterized, autopsy-matched iPSC lines provide a valuable resource to create neural derivatives that can be directly compared to corresponding brain tissue, enabling more physiologically relevant PD modeling and downstream therapeutic or biomarker studies even though the paper does…

We generated three donor-matched induced pluripotent stem cell (iPSC) lines from postmortem dura-derived fibroblasts obtained from donors with neuropathologically confirmed Alzheimer's disease (AD), Parkinson's disease (PD), and primary age-related tauopathy (PART) with TDP-43 co-pathology. All lines exhibited characteristic features of the undifferentiated human pluripotent stem cell (hPSC) state and maintained donor-specific genomic identity with stable variant profiles. These well-characterized iPSC lines provide valuable resources for modeling neurodegenerative diseases and for generating isogenic neural derivatives comparable to autopsy brain tissues from the same individuals.