This paper presents the GP2 Genome Browser, an open-access resource harmonizing 31,665 WGS and 9,559 CES samples across 11 ancestries with >300 million variants, providing ancestry-stratified allele frequencies and functional annotations for PD variant interpretation.

By delivering a large, ancestry-aware, and uniformly processed PD genomic dataset with convenient variant- and gene-level summaries, the browser materially accelerates identification and prioritization of risk and causal variants for target nomination, cohort stratification, and biomarker…

BACKGROUND: Large-scale sequencing initiatives have generated extensive genomic resources essential for variant interpretation, yet their effective use often requires bioinformatics expertise. To support identification of Parkinson's disease (PD) risk and disease-causing variants, we developed an open-access, summary-level genomic data browser. METHODS: We performed uniform joint variant calling to harmonize whole-genome sequencing (WGS) data from AMP-PD Release 4, GP2 Data Releases, and additional controls from the Alzheimer's Disease Sequencing Project. Clinical-exome sequencing (CES) data from GP2 Release 8 were also included. RESULTS: The integrated dataset included 31,665 WGS and 9,559 CES samples, spanning 11 ancestries and over 300 million variants. CONCLUSIONS: The GP2 Genome Browser is a lightweight, flexible platform providing intuitive gene- and variant-level summaries with ancestry-stratified allele frequencies and functional annotations. It is open source and freely accessible at https://gp2.broadinstitute.org, enabling broad access to PD genomic data and supporting global research efforts. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.