Comprehensive review of deep brain stimulation covering its historical development, current clinical targets (including STN for Parkinson's), technological advances (directional leads, rechargeable implants), and future directions such as closed-loop and imaging-guided approaches.

Clinically relevant for Parkinson's translational work because it synthesizes proven neuromodulation strategies and emerging DBS technologies that can inform therapeutic implementation and device-based trials, but it provides limited novel mechanistic or target-discovery insights for drug…

Deep brain stimulation (DBS) has emerged as a revolutionary neurosurgical treatment for various movement and psychiatric disorders. Its development, rooted in advances in stereotactic surgery and early thalamotomies, led to its FDA approval for essential tremor (1997) and Parkinson's disease (2002), followed by applications in dystonia, obsessive-compulsive disorder (OCD), and epilepsy. While DBS has proven effective in these domains, research continues to explore its potential for treating conditions like Alzheimer's disease, addiction, and depression. Despite its clinical success, the underlying mechanisms of DBS remain poorly understood, motivating ongoing studies on neural circuitry modulation. Current DBS applications focus on specific brain targets, such as the subthalamic nucleus for Parkinson's and the anterior nucleus of the thalamus for epilepsy, with new targets under investigation for conditions like OCD and chronic pain. Technological advancements in DBS hardware, including rechargeable implants and directional electrodes, have improved patient outcomes by enhancing precision and reducing side effects. Furthermore, innovations in neuroimaging and closed-loop DBS systems are expanding the capabilities of DBS, offering personalized treatments based on real-time neural feedback. This review highlights the historical evolution, current clinical applications, and future directions of DBS as a transformative therapy for neurological and psychiatric disorders.