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RESEARCH PAPER

Exosomal miR-1278 From Bone Marrow Mesenchymal Stem Cells Modulates Ldha-Mediated Microglia Polarization to Decelerate Parkinson's Disease Pathology.

PMID

42026401

Journal

Neuromolecular medicine

Publication Date

2026-04-23

Grade

AI Summary

Bone marrow mesenchymal stem cell-derived exosomes carrying miR-1278 modulate LDHA-dependent microglial polarization and attenuate Parkinson's-like pathology in preclinical models.

Why It Matters

Identifies a mechanistic, targetable axis connecting exosome-delivered miRNA, microglial metabolic/inflammatory state and neuroprotection, supporting development of exosome- or LDHA/miR-1278-focused therapeutic strategies for Parkinson's disease.

Abstract

Score Breakdown

AI Score

65.0

Base Score

11.9

Rank Score

13.1

Narrative Velocity

AI Confidence

NEUROCOMPUTE VISUAL SYSTEM