This study reports that curcumin and ferulic acid activate PPARγ–PGC1α signaling and rescue mitochondrial function in a 6‑OHDA cellular model of Parkinson's disease.

Targeting the PPARγ–PGC1α mitochondrial biogenesis pathway is directly relevant to PD neurodegeneration and these natural compounds represent easily testable leads for neuroprotective repurposing, though findings are limited to an in vitro model and need in vivo/PK and efficacy validation.