OBJECTIVE: Chronic illness is interpreted not only in terms of personal symptoms, but also through broader systems of meaning concerning family continuity and future generations. The present research introduces Intergenerational Taint Perception (ITP), a psychological meaning system through which individuals understand their illness as having symbolic and relational implications for their family line and descendants, independent of confirmed biological transmission. METHODS AND MEASURES: Across three studies with patient samples in China (total N = 942), we examined the emergence, structure, and behavioral consequences of ITP using qualitative, psychometric, and experimental methods. Study 1 used qualitative interviews with individuals living with Parkinson's disease to identify recurring intergenerational concerns in illness narratives. Study 2 developed and validated a 12-item ITP scale and examined its factor structure and discriminant validity from internalized stigma and attributional beliefs. Study 3 experimentally examined ITP across Parkinson's disease, type 2 diabetes, and ischaemic stroke, assessing protective buffering and willingness to seek formal support. RESULTS: Study 1 identified recurring concerns regarding descendants, family continuity, and anticipated burden in illness narratives. Study 2 supported a stable two-factor structure of ITP and demonstrated discriminant validity from internalized stigma and attributional beliefs. Study 3 showed that family-focused attention selectively increased ITP under conditions of perceived hereditary ambiguity. Elevated ITP predicted greater protective buffering and reduced willingness to seek formal support, and accounted for experimental effects beyond internalized stigma. CONCLUSION: These findings identify ITP as a distinct form of intergenerational illness meaningmaking that shapes health behavior. The results highlight the importance of family- and future-oriented interpretations of illness and suggest new targets for intervention in family-centerd health contexts.