A grade PMID 42321916
View analysis →Finding therapies hidden in 37,300 pediatric cancer papers.
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Ranked Discovery Journal Articles
A grade PMID 42372741
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All ranked pediatric cancer papers
This report describes a 5-year-old girl with Gorlin-Goltz syndrome, a large cardiac fibroma, and infection-associated ventricular fibrillation who underwent partial tumor resection and had no sustained ventricular arrhythmia recorded over nine months of postoperative monitoring.
The case provides preliminary evidence that partial resection is feasible and was followed by an arrhythmia-free monitored interval; it supports—but does not establish—the hypothesis that reducing cardiac fibroma burden may lower recurrent ventricular fibrillation risk when complete resection is impractical.
In a prospective cohort of childhood cancer survivors, urinary ATP, NGF, proNGF, BDNF, and creatinine showed poor discrimination for lower urinary tract dysfunction, while prior pelvic radiation was associated with increased odds of abnormal uroflow.
The study provides evidence that the evaluated urinary biomarkers are not useful screening tools in this setting; it supports only the inference that developing alternative objective screening approaches for pelvic-radiation–associated dysfunction could enable earlier recognition and management of treatment-related morbidity.
This retrospective pediatric neuroblastoma imaging study reports that mild, stable peripheral-ganglia uptake is common on 18F-MFBG PET/CT and that PET quantitative thresholds, combined with CT morphology, can help distinguish sympathetic ganglia from metastatic lymph nodes.
The evidence supports 18F-MFBG uptake patterns and candidate SUVmax thresholds as diagnostic discriminators; by inference, recognizing physiological ganglion uptake could reduce false-positive metastatic classification and improve staging or treatment selection, but no therapeutic intervention or outcome benefit was tested.
In a retrospective adult cohort with colorectal cancer liver metastases progressing after first-line therapy, irinotecan-loaded 100–300 μm and 300–500 μm beads used for TACE showed no statistically significant differences in response, survival, or adverse reactions.
The evidence suggests that both bead-size ranges may provide similar outcomes when DEBIRI-TACE is used as second-line treatment for colorectal liver metastases; it is only an inference—not demonstrated equivalence—that bead size could therefore be selected according to technical or patient-specific considerations, and the record provides no pediatric evidence.
This comprehensive review synthesizes epidemiology, clinical manifestations, diagnostic approaches, treatment regimens, complications, and preventive evidence for miliary tuberculosis, including CNS disease, drug-resistant infection, TB-IRIS, and childhood BCG vaccination.
The supplied review reports established and emerging management approaches—including prolonged CNS-directed therapy, dexamethasone for CNS complications, individualized drug-resistant regimens, and TNF-α antagonists as salvage therapy for steroid-refractory TB-IRIS; it can only be inferred, not concluded from this record, that these insights might help manage tuberculosis in immunocompromised pediatric oncology patients, because that population is not specifically evaluated.
In a retrospective single-center cohort of 86 predominantly older adults with cirrhosis and hepatocellular carcinoma treated with transarterial radioembolization, ALBI was the strongest survival predictor, while tumor burden had limited prognostic relevance.
The evidence supports ALBI as a prognostic marker after TARE; it may help stratify patients or guide treatment selection and monitoring, but prospective evidence that ALBI-guided decisions improve outcomes is not provided.
In three pediatric patients with medulloblastoma or pineoblastoma, rapid post-proton-CSI total-body PET/CT visualized irradiation-associated activity across the craniospinal axis and its time-dependent redistribution and decline throughout the body.
The study directly supports the feasibility of dynamic total-body imaging after proton craniospinal irradiation; it is an inference, not demonstrated here, that this approach could eventually aid treatment verification, workflow optimization, or assessment of proton-induced activity and washout.
This retrospective five-patient MEN2B case series reports that infant or early-childhood extra-endocrine manifestations—including chronic constipation, congenital clubfoot, and alacrimia—prompted RET testing and diagnosis before or near endocrine disease onset, enabling timely surgical management.
The reported cases support early recognition of characteristic extra-endocrine features as a trigger for RET testing; it is plausible, but not established by this uncontrolled series, that this pathway could enable thyroidectomy before metastatic medullary thyroid carcinoma and thereby improve outcomes.
This narrative review synthesizes evidence on HPV vaccination in adults aged 18–45 years, reporting associations with reduced HPV infection and persistence while noting widely variable estimates for prevention of high-grade cervical lesions and considering recurrence, cancers, and anogenital warts.
Evidence summarized in the review suggests that adult HPV vaccination may reduce some HPV infections and viral persistence; it is an inference, not established by this record, that broader life-course vaccination could prevent HPV-related cancers or post-treatment recurrence, particularly given heterogeneous lesion outcomes and absent study-level details.
In a prospective multicentre cohort of 91 patients under 18 years scheduled for allogeneic HSCT, 49% reported oral symptoms, 37% had dental caries, and substantial proportions underwent pre-transplant extractions or restorations.
The study directly supports a substantial and potentially actionable pre-transplant oral disease burden; it is reasonable—but not demonstrated by this record—to hypothesize that systematic dental evaluation and treatment before allogeneic HSCT could reduce infectious or other post-transplant complications.
The study reports that Zataria multiflora extract combined with cytarabine increased apoptosis in NALM-6 pre-B ALL cells, accompanied by an increased BAX/BCL2 expression ratio and reduced hTERT mRNA, while docking suggested a possible MDM2 interaction.
The reported cell-line findings support the hypothesis that Zataria multiflora extract may sensitize pre-B ALL cells to cytarabine; whether this permits safer or more effective treatment through apoptosis, telomerase, or MDM2-p53 modulation remains an inference requiring compound standardization, mechanistic validation, in vivo testing, and human safety data.
The record describes a severe recurrent laryngotracheal papillomatosis case in which airway patency was reportedly achieved using a Y-shaped tracheobronchial stent together with adjuvant bevacizumab.
The reported case supports feasibility of combined mechanical airway stabilization and bevacizumab in severe recurrent disease; it can only be inferred—not established—that this approach might provide rescue or palliation for selected patients whose airway obstruction is inadequately controlled by surgery.