Neurocompute scores pediatric oncology literature, surfaces overlooked therapeutic signals, and turns fragmented childhood cancer research into a living discovery terminal.
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View analysis →A co-designed virtual educational prototype on triadic communication was delivered to 12 multidisciplinary professionals in adolescent and young adult cancer care, whose interview feedback emphasized accessibility, attention to the young person's voice and time alone, and a desire for skills practice.
The study provides preliminary evidence that professionals value this communication training; it is plausible, but not demonstrated here, that refined training with roleplay could improve youth-centered communication and ultimately care experiences or outcomes.
In 34 unrelated Greek probands with definite or possible tuberous sclerosis complex, targeted TSC1/TSC2 sequencing identified pathogenic or likely pathogenic variants in 22 patients, including seven previously unreported variants, with an exploratory trend toward greater severity among TSC2 carriers.
The study provides evidence that TSC1/TSC2 testing can improve molecular diagnosis and counseling in this population; it is plausible, but not demonstrated here, that variant classification could eventually support risk-adapted surveillance or selection of mTOR-directed management.
This prospective cross-sectional study reports reduced postoperative choroidal thickness at most measured retinal locations in children with surgically treated adamantinomatous craniopharyngioma compared with matched healthy controls, with selected associations involving birthplace and cavernous sinus infiltration.
The evidence supports choroidal thickness as a potential ocular biomarker of postoperative changes associated with pediatric craniopharyngioma; it is only an inference that longitudinal OCT monitoring could help identify visual risk or guide supportive ophthalmic management, because treatment prediction, intervention response, and clinical outcomes were not evaluated.
In 20 adult patients with childhood- or adult-onset craniopharyngioma or CNS germ cell tumor, social participation and physical activity were lower than in 25 healthy participants, while greater apathy correlated with lower productivity.
The study provides observational evidence linking apathy with reduced productivity; it is reasonable but untested to hypothesize that apathy-targeted behavioral support, caregiver-assisted activity planning, or rehabilitation could improve social participation and physical activity.
In a multicenter cross-sectional study of 421 Chinese adolescent and young adult cancer survivors, self-reported global cognitive complaints were associated with substantially higher odds of limitations in work/school and home duties.
The evidence supports cognitive-complaint phenotyping as a potential marker of survivors at risk for role-functioning limitations; it remains an untested inference that phenotype-guided screening, cognitive rehabilitation, or supportive interventions would improve functioning.
This narrative review describes rising early-onset gastrointestinal cancer incidence, age-associated diagnostic and psychosocial challenges, uncertain benefit from more intensive treatment, and limited access to specialized multidisciplinary care programs.
The review reports unmet needs and existing multidisciplinary care models; it supports the inference that scalable, age-tailored programs addressing timely diagnosis, treatment intensity, fertility, psychosocial distress, and financial toxicity could improve care, but the supplied record provides no comparative outcomes or evidence of therapeutic efficacy.
In children with pneumonia, the study reports higher miR-27a-5p in severe disease, diagnostic and prognostic associations, and cell-based evidence that miR-27a-5p targets FOXO1 and affects viability, apoptosis, and inflammatory-factor production.
The evidence supports an association between elevated miR-27a-5p and severe pediatric pneumonia plus a miR-27a-5p–FOXO1 interaction in HFL1 cells; it can be inferred, but is not clinically demonstrated, that inhibiting miR-27a-5p or restoring FOXO1 might reduce inflammatory injury.
The paper reports an NCI childhood-cancer Data Jamboree in which more than 120 participants formed 23 multidisciplinary teams to reuse shared data, develop projects, and provide recommendations for improving cancer-data utility.
The reported evidence supports the feasibility of a community-wide, FAIR-oriented collaborative data event; it is reasonable but unproven to hypothesize that sustained use of this model could accelerate discovery of diagnostic or therapeutic opportunities in rare pediatric cancers.
A mixed-methods survey of 117 MASCC respondents found broad belief in the oncology relevance of the gut microbiome and substantial interest in microbiome programs, alongside perceived deficits in evidence, expertise, funding, infrastructure, and standardized research practices.
Evidence from this record is limited to professional practices and perceptions; it supports the inference that improved infrastructure, expertise, and standardization could enable trials of microbiome-based sampling or interventions, but it does not show that any microbiome-directed therapy improves efficacy, toxicity, or outcomes in pediatric or adult patients.
In 30 neuroblastoma cases, a whole-slide-image deep learning model reportedly classified four risk/MYCN groups with 98% accuracy and MYCN amplification status with 99% accuracy, including 96% discrimination within high-risk cases.
The evidence supports a preliminary diagnostic-assistance signal rather than a treatment effect; if independently validated, histology-based AI prediction of risk group and MYCN status could inform treatment selection when molecular testing is delayed or unavailable.
This case report describes a 12-year-old girl with primary hyperparathyroidism from a parathyroid adenoma presenting as genu valgum and multifocal brown tumors, with biochemical normalization and substantial clinical and radiological improvement after radiofrequency ablation.
The reported case provides evidence that treating the identified parathyroid lesion can reverse biochemical abnormalities and may improve PHPT-associated skeletal disease; it is reasonable but unproven to infer that early endocrine testing and targeted treatment could prevent unnecessary orthopedic or oncologic procedures in similar children.
This single-infant case report describes post-neurosurgical meningitis caused by ESBL-producing, virulence-associated Klebsiella pneumoniae ST37 after tumor resection and EVD placement, with CSF sterilization following meropenem and EVD removal but persistent neurological sequelae.
The case provides direct but very limited evidence that prompt active antimicrobial therapy plus removal of an infected ventricular device can achieve microbiological clearance; it supports the hypothesis—not established by this report—that resistance-informed empiric therapy and early source control may improve outcomes in similarly exposed infants.
