Neurocompute scores pediatric oncology literature, surfaces overlooked therapeutic signals, and turns fragmented childhood cancer research into a living discovery terminal.
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View analysis →In a single-center retrospective cohort of 119 children with posterior fossa tumors, neuro-ophthalmological abnormalities were frequent at diagnosis, after surgery, and at relapse, with postoperative oculomotor disorders associated with vermis/brainstem location, medulloblastoma, and cerebellar mutism syndrome.
The study provides observational evidence that serial ophthalmologic and orthoptic assessment identifies clinically relevant, evolving deficits; it is reasonable—but not tested here—to hypothesize that risk-adapted surveillance and timely prism or surgical correction could reduce long-term visual and functional morbidity.
This single-institution retrospective series reports five boys with lymphoma presenting as genitourinary masses, in whom biopsy and recognition of systemic disease enabled chemotherapy-based management with four complete remissions and avoidance of radical resection in most cases.
The reported evidence suggests that early image-guided biopsy and systemic staging can distinguish lymphoma from primary genitourinary tumors and may preserve organs by directing patients to systemic chemotherapy; whether a standardized diagnostic pathway reliably improves outcomes or reduces surgery requires larger comparative studies.
This protocol describes a systematic review and planned meta-analysis of the diagnostic accuracy of growth hormone stimulation tests after radiotherapy involving the hypothalamic-pituitary axis across pediatric and adult populations.
The record establishes only a plan to synthesize diagnostic evidence; if the review identifies reliable test-specific accuracy or clinically meaningful modifiers, it could improve detection and treatment selection for post-radiotherapy growth hormone deficiency, but no diagnostic or therapeutic benefit has yet been demonstrated.
The study reports that CD155 supports both immune evasion and cell-autonomous growth in diffuse midline glioma, while CD155 or FOXM1 suppression and thiostrepton treatment produce antitumor effects in preclinical models.
The supplied evidence shows that CD155 silencing enhances CD8+ T-cell-mediated killing, induces tumor-cell apoptosis, and restricts DMG growth in mice, with FOXM1 implicated downstream; it therefore supports—but does not clinically establish—the hypothesis that targeting the CD155–FOXM1 axis could combine immune sensitization with direct tumor control in DMG.
This retrospective multinational multicentre study of 86 prophylaxis courses in children with newly diagnosed AML reports the tolerability, toxicity, and exploratory breakthrough fungal infection rate associated with extended-dosing liposomal amphotericin B.
The study provides observational evidence that extended-dosing liposomal amphotericin B can deliver mould-active prophylaxis with a 3% observed breakthrough proven or probable invasive fungal disease rate, but it is only an inference—not established comparative evidence—that this regimen could be a useful alternative when triazoles are contraindicated or daily echinocandin administration is impractical.
This prospective COG study reports that female adolescents and young adults with lymphoma had lower AMH than healthy peers at diagnosis and one year after treatment, with low baseline AMH and greater alkylator exposure independently predicting diminished ovarian reserve.
The evidence supports using baseline AMH and alkylator exposure as risk-stratification factors for post-treatment diminished ovarian reserve; it is reasonable, but not tested here, to hypothesize that this information could guide earlier fertility-preservation counseling or selection of less gonadotoxic treatment when oncologically appropriate.
This systematic review and meta-analysis of 39 cohort studies reports that childhood, adolescent, and young adult cancer survivors have nearly twice the cardiovascular disease risk of cancer-free peers, with the highest relative risk among childhood cancer survivors.
Evidence supports age-specific, long-term cardiovascular risk surveillance after CAYA cancer; it is an inference—not tested here—that surveillance paired with targeted prevention or early intervention could reduce cardiovascular morbidity or mortality.
In a retrospective cohort of 103 children with severe Mycoplasma pneumoniae pneumonia, adding ambroxol to montelukast plus azithromycin was associated with higher reported clinical efficacy and improvements in inflammatory, immune, and pulmonary measures, without an observed increase in adverse reactions.
The record provides observational evidence that adjunctive ambroxol may improve recovery in pediatric severe Mycoplasma pneumoniae pneumonia; it is only an inference that modulation of airway clearance or inflammatory and immune markers causes this benefit, and no pediatric-cancer-specific therapeutic effect is evaluated.
This systematic review of 77 studies reports consistent evidence that supervised, moderate-intensity physical activity during pediatric cancer treatment can improve exercise capacity and strength, inconsistent effects on physical function, and emerging evidence that nutrition interventions may improve diet quality.
The reviewed evidence supports physical activity as a potentially useful supportive-care intervention for exercise capacity and strength; it is reasonable but not established to hypothesize that combined nutrition and activity programs could preserve function or improve treatment experience, because standardized clinical outcomes and evidence of effects on toxicity, treatment completion, or survival were not reported.
In a cross-sectional CMR study of 109 children with leukemia and 40 age-matched controls, anthracycline exposure—particularly at higher cumulative doses—was associated with altered left atrial function, impaired LA-LV coordination, and elevated left atrioventricular coupling index.
The reported human imaging associations support CMR-derived LA strain and LACI as candidate markers of anthracycline-related cardiac dysfunction; it remains an inference, requiring prospective validation, that these measures could enable earlier cardioprotective intervention or guide chemotherapy monitoring to reduce cardiotoxicity.
In a retrospective cohort of 72 pediatric gonadal germ cell tumors, a targeted-sequencing signature defined by at least two qualifying genomic alterations was associated with worse event-free survival after stage adjustment, but not significantly different overall survival.
Evidence: signature-positive tumors had inferior event-free survival and a stage-adjusted EFS hazard ratio of 2.74. Inference: if independently validated, this genomic signature could complement conventional risk factors for surveillance, trial stratification, or treatment-selection research, but the record does not support treatment escalation or a specific targeted therapy.
This systematic review of 37 reports describing 47 individuals with constitutional trisomy 8 mosaicism found predominantly childhood- or adolescent-onset myeloid malignancies, especially MDS and AML, often without an overt syndromic phenotype and with generally poor reported outcomes.
The reported evidence supports targeted evaluation for constitutional trisomy 8 mosaicism in selected pediatric MDS or persistent-trisomy-8 cases; it is an untested inference that earlier recognition could improve surveillance, diagnostic classification, treatment planning, or counseling, and the review does not establish a therapy or clinical benefit.
