Neurocompute scores pediatric oncology literature, surfaces overlooked therapeutic signals, and turns fragmented childhood cancer research into a living discovery terminal.
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View analysis →This study translated and culturally adapted the Fertility Intention Scale into Korean and found preliminary, generally acceptable reliability and validity in secondary data from 203 women aged 18–45 years with breast cancer.
The evidence supports the K-FIS as a preliminary assessment tool for fertility intentions; it may, by inference, help clinicians tailor fertility counseling or supportive interventions, but the record does not demonstrate improved treatment decisions, fertility outcomes, or cancer outcomes.
In a nationally surveyed sample of 5,375 girls and young women aged 15–20 years, routine cervical cancer overscreening declined from 22.1% in 2011 to 4.5% in 2023 but remained associated with sexual history and, increasingly, concurrent STI testing.
The evidence identifies STI-testing encounters and sexual-history-based practice as potential targets for deimplementation efforts; it is an inference, not tested here, that guideline prompts or clinician education during these encounters could reduce unnecessary screening and related harms.
In a retrospective cancer-center cohort of 369 predominantly adult patients with actinic keratosis, multiple contiguous lesions were associated with incomplete clinical response, while follow-up loss was high and complete clearance after field-directed therapy was limited.
The observed associations suggest—but do not establish—that lesion distribution and patient factors could be used to tailor actinic keratosis management and follow-up intensity; no pediatric-specific intervention, comparative treatment benefit, or causal therapeutic effect is demonstrated.
This two-institution series describes eight pediatric CIC::NUTM1-rearranged undifferentiated round cell sarcomas, defines their clinicopathologic and molecular features, reports poor outcomes, and proposes an immunohistochemical screening panel.
The evidence supports improved recognition of an aggressive pediatric sarcoma subtype using NUT, CD99, WT1, and DUX4 staining followed by fusion confirmation; it is only an inference that more accurate classification could guide treatment selection or future fusion-directed research, because no therapy-specific response or intervention was evaluated.
This single-center retrospective study of 452 auto-HCT recipients treated from 1999 to 2014 reports that overall and progression-free survival continued to decline beyond 10 years, while a significant but unquantified proportion survived for 20 years.
The record supports long-term durability of auto-HCT for some patients with hematologic disorders; it is reasonable—but inferential—to hypothesize that disease- and risk-factor analyses could improve transplant selection and long-term surveillance, although pediatric-specific benefit is not demonstrated.
This preliminary human-sample study developed a Luminex multiplex assay using commercial L1 proteins from seven HPV types and reported strong IgG performance for several types, correlated IgA and IgG signals, and discrimination among blinded antibody-response groups.
The record supports the assay as a potential scalable tool for measuring type-specific HPV vaccine antibody responses; by inference, after further standardization and clinical validation, it could help assess population immunity or vaccination programs relevant to preventing HPV-associated cancers, but it does not establish treatment selection, cancer outcomes, or protective antibody thresholds.
In a Swedish register-based matched cohort, children with cancer had more primary healthcare contacts before diagnosis than cancer-free references, while socioeconomic gradients largely disappeared except in CNS tumours, where lower maternal education was associated with 28% more prediagnostic contacts.
The evidence identifies an association between lower maternal education and greater prediagnostic primary-care use for CNS tumours; it may therefore justify testing—rather than currently support—targeted diagnostic pathways or referral support to reduce possible delays and improve timely diagnosis.
This report describes planned two-stage prosthetic rehabilitation in a 14-year-old boy after maxillary odontogenic myxoma resection, using an immediate interim obturator followed by a definitive prosthesis after 30 days, with favorable local recovery and reported quality-of-life benefit.
Evidence from this single case suggests that preoperative prosthetic planning and immediate interim obturation can tamponade an oronasal defect, support hemostasis, protect the wound, and facilitate later definitive rehabilitation; it is reasonable but unproven to hypothesize that this approach improves functional and psychosocial recovery across pediatric patients undergoing maxillary tumor resection.
In interviews with seven pediatric cancer survivors from Newfoundland and Labrador, the study identified themes involving isolation, school-based stigma, social support, inadequate professional mental-health support, resilience, and disability-related workplace experiences.
The reported experiences suggest—but do not test—that survivor-focused mental-health services, school anti-stigma measures, and tailored social-support programs could reduce isolation and improve psychosocial outcomes after pediatric cancer.
In a single-center retrospective cohort of 147 patients with C-TIRADS 4a/b thyroid nodules, a logistic-regression model combining clinical characteristics with intralesional and perilesional ultrasound radiomics achieved a validation AUC of 0.866 for malignancy classification.
The evidence supports a potential non-invasive diagnostic aid for malignancy risk stratification; it may, by inference, improve biopsy or management selection and reduce unnecessary procedures, but the record provides no evidence of treatment effects, improved patient outcomes, or pediatric-specific utility.
In 19,041 patients from 13 French cancer registries, social deprivation, travel time to a reference center, and primary-care accessibility were associated with excess mortality in selected hematological malignancies, with the relevant factor differing by malignancy.
The evidence supports prognostic associations rather than an intervention; it may be hypothesized that improving referral-center access, primary-care availability, or support for socially deprived patients could reduce excess mortality in selected hematological malignancies, but causality and pediatric benefit were not tested.
In a retrospective two-center cohort of 912 patients with breast cancer, a model combining DCE-MRI radiomics with sentinel lymph node status, ER status, and time-intensity curve characteristics predicted pathological lymphovascular invasion better than the standalone radiomics or clinical models, with an external-test AUC of 0.703.
Evidence: the combined model showed moderate discrimination, calibration, and decision-curve net benefit for preoperative LVI prediction in retrospective data. Inference: after prospective validation and workflow testing, such risk estimates might help tailor surgery or systemic-treatment planning, but this record does not demonstrate improved treatment selection, outcomes, or applicability to pediatric oncology.
