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RESEARCH PAPER ANALYSIS

Pediatric Hemispheric High-Grade Gliomas and H3.3-G34 Mutation: A Review of the Literature on Biological Features and New Therapeutic Strategies.

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PMID39202398
JournalGenes
Publication Date2024-08-06
Ingested2026-08-02 12:02 AM
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ABSTRACT

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Pediatric high-grade glioma (pHGG) encompasses a wide range of gliomas with different genomic, epigenomic, and transcriptomic features. Almost 50% of pHGGs present a mutation in genes coding for histone 3, including the subtype harboring the H3.3-G34 mutation. In this context, histone mutations are frequently associated with mutations in TP53 and ATRX, along with PDGFRA and NOTCH2NL amplifications. Moreover, the H3.3-G34 histone mutation induces epigenetic changes in immune-related genes and exerts modulatory functions on the microenvironment. Also, the functionality of the blood-brain barrier (BBB) has an impact on treatment response. The prognosis remains poor with conventional treatments, thus eliciting the investigation of additional and alternative therapies. Promising molecular targets include PDGFRA amplification, BRAF mutation, EGFR amplification, NF1 loss, and IDH mutation. Considering that pHGGs harboring the H3.3-G34R mutation appear to be more susceptible to immunotherapies (ITs), different options have been recently explored, including immune checkpoint inhibitors, antibody mediated IT, and Car-T cells. This review aims to summarize the knowledge concerning cancer biology and cancer-immune cell interaction in this set of pediatric gliomas, with a focus on possible therapeutic options.

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The Journal of the Pakistan Medical Association 67.12 9 Preoperative identity Threat and Illness Perception in Patients Undergoing Resection of Intracranial Tumours: A Multidimensional Cross-sectional Study Using Validated Psychometric Instruments. JPMA. The Journal of the Pakistan Medical Association 63.4 10 Childhood and Adolescent Central Nervous System Tumour Mortality in the United States, 1999- 2024: A CDC WONDER Joinpoint Analysis and Surveillance Model for Pakistan. JPMA. The Journal of the Pakistan Medical Association 57.5 11 Paediatric Scalp Squamous Cell Carcinoma With Suspected Intracranial Extension Mimicking Cerebral Abscesses in a Patient With Xeroderma Pigmentosum: A Case Report and Literature Review Abstract. JPMA. The Journal of the Pakistan Medical Association 49.9 12 Recurrence to persistence: Inflammatory markers in pediatric rheumatic heart disease. Annals of pediatric cardiology 58.5 13 Prevalence and genotype distribution of human papillomavirus (HPV) among adolescent girls and young women in a high HIV burden rural area of South Africa: a cross-sectional survey. medRxiv : the preprint server for health sciences 61.0 14 Delayed B-cell reconstitution in the bone marrow precedes the development of chronic graft-versus-host disease following pediatric hematopoietic stem cell transplantation. Frontiers in immunology 61.7 15 Parental and childhood exposures and the risk of retinoblastoma, hepatoblastoma, and germ cell, bone, and soft tissue tumors in children: a systematic review and meta-analysis. Frontiers in oncology 73.0 16 Clinical outcomes in pediatric acute lymphoblastic leukemia: a retrospective cohort study from a tertiary center in Indonesia. Frontiers in pediatrics 62.7 17 PROX1-associated lymphatic reprogramming signatures in pediatric adamantinomatous craniopharyngioma: a comparative study with adult cases. 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World journal for pediatric & congenital heart surgery 58.4 30 Palliative Care Support for Pediatric Cancer Patients Enrolled in Phase I Clinical Trials. Journal of palliative medicine 78.8 31 Acute abdominal presentation of mantle cell lymphoma mimicking acute appendicitis: a case report. Journal of surgical case reports 47.5 32 AGA Clinical Practice Update on Surveillance of Pancreatic Cystic Lesions and Hepatocellular Carcinoma in Older Adults: Expert Review. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 75.9
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Pediatric Hemispheric High-Grade Gliomas and H3.3-G34 Mutation: A Review of the Literature on Biological Features and New Therapeutic Strategies.

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