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RESEARCH PAPER ANALYSIS

CAR T cell therapy for pediatric central nervous system tumors: a review of the literature and current North American trials.

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PMID39251462
JournalCancer metastasis reviews
Publication Date2024-09-09
Ingested2026-08-02 12:02 AM
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ABSTRACT

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Central nervous system (CNS) tumors are the leading cause of cancer-related death in children. Typical therapy for CNS tumors in children involves a combination of surgery, radiation, and chemotherapy. While upfront therapy is effective for many high-grade tumors, therapy at the time of relapse remains limited. Furthermore, for diffuse intrinsic pontine glioma (DIPG) and diffuse midline glioma (DMG), there are currently no curative therapies. Chimeric antigen receptor T (CAR T) cell therapy is a promising novel treatment avenue for these tumors. Here, we review the preclinical evidence for CAR T cell use in pediatric brain tumors, the preliminary clinical experience of CNS CAR T cell trials, toxicity associated with systemic and locoregional CAR T cell therapy for CNS tumors, challenges in disease response evaluation with CAR T cell therapy, and the knowledge gained from correlative biologic studies from these trials in the pediatric and young adult population.

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CAR T cell therapy for pediatric central nervous system tumors: a review of the literature and current North American trials.

For education only—not personal medical advice.

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