← Back to all signals
RESEARCH PAPER ANALYSIS

Comparison of 68Ga-DOTANOC and 18F-FDOPA PET/CT for Detection of Recurrent or Metastatic Paragangliomas.

AI interpretation is pending for this paper.

Open original publication →
PMID39641622
JournalRadiology. Imaging cancer
Publication Date2025-01-01
Ingested2026-08-02 12:03 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

Purpose To evaluate the diagnostic performance of gallium 68 (68Ga)-DOTA-NaI3-octreotide (68Ga-DOTANOC) and fluorine 18 (18F)-fluoro-l-3,4-dihydroxyphenylalanine (18F-FDOPA) PET/CT in detecting recurrent or metastatic paragangliomas. Materials and Methods This single-center retrospective study included patients with paragangliomas who underwent both 68Ga-DOTANOC PET/CT and 18F-FDOPA PET/CT between August 2021 and December 2023. The diagnostic performance of these two tracers in detecting recurrent or metastatic tumors was compared using several metrics, including sensitivity, negative predictive value, and accuracy. Results This study included 36 patients (median age, 52 years [range, 14-78 years]; 16 female, 20 male). Of these, nine underwent initial 68Ga-DOTANOC and 18F-FDOPA PET/CT examinations before treatment, and the remaining 27 underwent posttreatment examinations. Twenty-two of those 27 patients had recurrence or metastasis. According to lesion-level analysis, 68Ga-DOTANOC had higher sensitivity, negative predictive value, and accuracy for diagnosis of bone metastases than did 18F-FDOPA PET/CT (97% vs 78% [P < .001], 85% vs 42% [P = .02], and 97% vs 81% [P < .001], respectively). 18F-FDOPA PET/CT had higher sensitivity, negative predictive value, and accuracy for the diagnosis of liver metastases than did 68Ga-DOTANOC PET/CT (73% vs 15% [P < .001], 68% vs 41% [P = .04], and 83% vs 46% [P < .001], respectively). According to patient-level analysis, the sensitivity of 18F-FDOPA PET/CT for diagnosing liver metastases was higher than that of 68Ga-DOTANOC PET/CT (88% vs 25%; P = .04). Conclusion In patients with recurrent or metastatic paragangliomas, 68Ga-DOTANOC PET/CT showed better performance than 18F-FDOPA PET/CT in detecting bone metastases, and 18F-FDOPA PET/CT performed better in detecting liver metastases. Keywords: 68Ga-DOTANOC, 18F-FDOPA, Pheochromocytoma, Paraganglioma Published under a CC BY 4.0 license.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Effects of nutritional intervention on insulin resistance-associated inflammatory biomarkers and gene polymorphisms in gestational diabetes mellitus. Journal of medical biochemistry 67.45 2 Factors influencing health-related quality of life in children with leukemia in Saudi Arabia: a cross- sectional study. BMC pediatrics 63.8 3 Breast Cancer Patients' Parenting Concerns User Personas: A Qualitative Analysis. Current oncology (Toronto, Ont.) 57.4 4 Molecular Pathogenesis, Tumor Microenvironment and Health Disparities in Select Pediatric Solid Tumors: An Integrative Narrative Review. Diseases (Basel, Switzerland) 65.5 5 Expression VIII: Final Results of the Individual Perception and Level of Information of Patients with Borderline Tumors of the Ovary. Current oncology (Toronto, Ont.) 67.8 6 Adolescents and young adults with cancer in Switzerland: a large retrospective single-centre cohort analysis of key care pathways and outcomes by sex and age. Swiss medical weekly 79.6 7 Cellular and Immunotherapy for Pediatric Brain Tumors: A Primer. Current oncology (Toronto, Ont.) 62.52 8 Exercise and Childhood Cancer: From Science to Life "The 3rd Pediatric Exercise Oncology Congress Meets FORTEe". Current oncology (Toronto, Ont.) 66.9 9 Mitochondrial Genomic Alterations in Pediatric Acute Lymphoblastic Leukemia: Implications for Methotrexate-Induced Neurotoxicity and Ethnic Disparities. Cancer medicine 58.62 10 Two-Decade Trends in Radiotherapy Patterns and Clinical Outcomes for Soft Tissue Sarcoma: A Nationwide Study in South Korea (2005-2023). Cancer medicine 72.64 11 Re-resection at first recurrence is associated with prolonged survival in young patients with high-grade glioma: A multi-center study. Neuro-oncology advances 71.92 12 Risk Modulation by Electronic Cigarette Consumption in Cardiovascular Disease and Its Relevance in Cardiac Surgery-A Narrative Review. Journal of cardiovascular development and disease 55.0 13 Management of ectopic Cushing syndrome in medullary thyroid carcinoma: from case reports to systematic literature review. Frontiers in endocrinology 86.1 14 Comparative efficacy and safety of pharmacologic, laser, and combination therapies for infantile hemangioma: a systematic review and network meta-analysis with evidence certainty assessment. Frontiers in pharmacology 82.8 15 A PDGFRB-CD44-MIF crosstalk promotes cancer-associated cellular phenotypes in ATRT-TYR/MYC cell lines. Frontiers in oncology 51.6 16 Case Report: Two cases of secondary malignant neoplasms following treatment in pediatric patients. Frontiers in pediatrics 61.14 17 Guanfacine and HCN channels: bridging neuroinflammation and prefrontal cortex function in autism spectrum disorder. Frontiers in molecular neuroscience 62.9 18 Clinical Outcomes and New Treatments in Pediatric Brain Tumors. Current oncology (Toronto, Ont.) 52.74 19 Quality of Life in Ukrainian Children and Adolescents with Cancer Relocated to Switzerland During the Russian-Ukrainian War: An Exploratory Multicenter Study. Current oncology (Toronto, Ont.) 59.9 20 Vitamin D and Gastric Cancer: A Systematic Review and Meta-Analysis. Medical sciences (Basel, Switzerland) 73.0 21 "If I want to tap into a cord blood bank later, I felt that I should do my part and donate": Mutualism in women's accounts of umbilical cord blood donation. Social science & medicine (1982) 56.0 22 Metabolic profiling of CAR T-cells in patients reveals a shift toward amino acid-supported OXPHOS and informs transporter engineering. Research square 58.8 23 Oncohistone inhibition reshapes tumor-microenvironment communication in Diffuse Midline Glioma (DMG). bioRxiv : the preprint server for biology 58.8 24 Prenatally Detected Neonatal Neuroblastoma Associated with Achondroplasia and an SDHA Variant. Neurology international 62.8 25 Preclinical evaluation of ixazomib for high-risk pediatric brain tumors. bioRxiv : the preprint server for biology 59.7 26 Fusion Oncoprotein EWSR1::FLI1 Invades Nucleosomes at Consensus ETS Motifs and GGAA Microsatellites. bioRxiv : the preprint server for biology 56.0 27 Genomic Characterization of RTK-RAS Pathway Alterations in Juvenile Myelomonocytic Leukemia Through Whole-Exome Sequencing. Medical sciences (Basel, Switzerland) 65.9 28 Management of intractable emergence agitation with emotional and behavioural disinhibition in a child with anxiety requiring multiple anaesthetics. Anaesthesia reports 60.0 29 [Spitz tumors]. Pathologie (Heidelberg, Germany) 56.0 30 Pasireotide-LAR and pegvisomant combination in resistant acromegaly: a case series of predominantly mammosomatotroph adenomas. Pituitary 61.4 31 Successful Cytotoxic Chemotherapy-Free Bridging to Hematopoietic Stem Cell Transplantation With Dasatinib and Prednisolone/Blinatumomab for Relapsed Pediatric Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia. Pediatric blood & cancer 55.06 32 Physical activity and exercise in pediatric oncology: conceptual distinctions and clinical implications. Turkish journal of physical medicine and rehabilitation 62.0
PATIENT-FRIENDLY SUMMARY

Comparison of 68Ga-DOTANOC and 18F-FDOPA PET/CT for Detection of Recurrent or Metastatic Paragangliomas.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic