Analysis of efficacy of picosecond laser treatment for nevus of Ota.
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To analyze the efficacy, safety, and influencing factors of 1064 nm picosecond Nd: YAG laser(PSAL)treatment for Nevus of Ota. From January 2018 to March 2024, 212 patients with Nevus of Ota were treated with 1064 nm picosecond Nd: YAG laser at the Guangzhou Dermatology Hospital. The study analyzed the impact of patient gender, age, Tanino classification of skin lesions, color of skin lesions, Fitzpatrick classification of skin, and number of treatments on efficacy, while also documenting any adverse reactions to the treatment. Overall, out of the 212 patients who underwent 1 to 11 treatment sessions, 80 cases (37.73%) achieved complete clearance, 42 cases (19.81%) showed excellent outcomes, 45 cases (21.22%) had good outcomes, 37 cases (17.45%) saw fair outcomes, and 8 cases (3.77%) had minimal effect, resulting in an overall effective rate of 78.77%. The study revealed a correlation between treatment efficacy, age, and the number of laser treatments (P < 0.05). Multifactorial logistic regression analysis demonstrated a positive association with treatment effectiveness (odds ratio 3.324; 95% confidence interval 2.110-5.238). Other variables such as gender, Tanino classification of skin lesions, color of skin lesions, and Fitzpatrick skin type showed no significant correlation with efficacy (P > 0.05). Among the patients, two experienced temporary post-inflammatory effects, while three exhibited folliculitis. Notably, there were no reported cases of persistent erythema, scarring, or hypopigmentation. The treatment of Nevus of Ota using 1064 nm picosecond Nd: YAG laser has been demonstrated to be both safe and effective, with treatment efficacy impacted by patient age and the number of treatment sessions. Early intervention and higher frequency of treatment sessions are associated with improved treatment outcomes.