← Back to all signals
RESEARCH PAPER ANALYSIS

The origin and polarization of Macrophages and their role in the formation of the Pre-Metastatic niche in osteosarcoma.

AI interpretation is pending for this paper.

Open original publication →
PMID39938167
JournalInternational immunopharmacology
Publication Date2025-02-11
Ingested2026-08-02 12:03 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

Osteosarcoma, a primary malignant bone tumor commonly found in adolescents, is highly aggressive, with a high rate of disability and mortality. It has a profound negative impact on both the physical and psychological well-being of patients. The standard treatment approach, comprising surgery and chemotherapy, has seen little improvement in patient outcomes over the past several decades. Once relapse or metastasis occurs, prognosis worsens significantly. Therefore, there is an urgent need to explore new therapeutic approaches. In recent years, the successful application of immunotherapy in certain cancers has demonstrated its potential in the field of cancer treatment. Macrophages are the predominant components of the immune microenvironment in osteosarcoma and represent critical targets for immunotherapy. Macrophages exhibit dual characteristics; while they play a key role in maintaining tumor-promoting properties within the microenvironment, such as inflammation, angiogenesis, and immune suppression, they also possess antitumor potential as part of the innate immune system. A deeper understanding of macrophages and their relationship with osteosarcoma is essential for the development of novel therapeutic strategies.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 [Childhood acute myeloid leukemia with TLS::ERG fusion gene: a clinical analysis of 12 cases]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 66.0 2 [Single-center application and analysis of neuroblastoma marker detection in childhood neuroblastoma]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 60.7 3 [Chemotherapy-related central nervous system injury in children with acute lymphoblastic leukemia: research progress]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 71.54 4 Combined Petrosectomy in a 7-Year-Old Patient: Case-Based Video Illustration and Technical Considerations for Petrosal Approaches in the Pediatric Population. Neurosurgery practice 47.5 5 MiR-331-3p serves as a diagnostic biomarker in children with severe pneumonia. BMC immunology 53.85 6 Investigating effects of alcohol-related breast cancer warnings and binge-drinking frequency on alcohol consumption intentions among young adult female participants in the United States. Health education research 64.2 7 Perceived Family Functioning, Family Resilience, and Multidimensional Sleep Problems Among Chinese Children and Adolescents With Cancer: The Indirect Association of Depression and Anxiety. Cancer medicine 69.4 8 Management Guidelines for the Treatment of Pediatric Brain Tumor-Associated Seizure: A Modified Delphi Consensus Report. Annals of the Child Neurology Society 75.94 9 Retrospective Analysis of T2-Hyperintense Lesions in Children With Neurofibromatosis Type 1. Annals of the Child Neurology Society 70.8 10 Education as advocacy: bringing pathology into the care of children with leukemia. Paediatrics & child health 57.2 11 Wilms tumor with rare spinal metastasis treated with surgery and chemotherapy: A case report. The Journal of international medical research 59.44 12 Newer antibiotics for drug-resistant Gram-negative infections in immunocompromised hosts: from pivotal trials to high-risk practice. Frontiers in cellular and infection microbiology 72.06 13 Current status of fertility preservation for borderline ovarian tumor in Asian countries: results from ASGO-special task force for fertility preservation; part II. Fertility and pregnancy planning following initial treatment. Journal of gynecologic oncology 59.24 14 Current status of fertility preservation for borderline ovarian tumor in Asian regions: results from ASGO-special task force for fertility preservation; part I. Fertility-sparing treatment for borderline ovarian tumor. Journal of gynecologic oncology 60.74 15 Real-world data sources for pediatric cancers: a targeted literature review. ESMO real world data and digital oncology 60.8 16 NSUN2 promotes glycolysis and stemness of retinoblastoma cells by m5C modification of PFKFB3. Tissue & cell 52.5 17 Hypersensitivity to PEG-Asparaginase and Desensitization Strategies in Pediatric Acute Lymphoblastic Leukemia: A Narrative Review. Acta medica academica 70.6 18 Cultural Beliefs and Perceptions of Breast Cancer Among Adolescent Girls in Semi-Urban Bangladesh: A School-Based Cross-Sectional Study. Public health challenges 64.0 19 Outcomes of down syndrome-related myeloid leukemia in Turkiye: a multicenter retrospective observational cohort study by the Turkish Pediatric Hematology Association. Annals of hematology 65.9 20 Nutrition and physical activity interventions delivered to children and young people during cancer treatment: a systematic literature review. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 73.44 21 Sclerosing angiomatoid nodular transformation of the spleen in an 18-year-old man: a case report. Journal of surgical case reports 45.5 22 Intraoperative MRI in pediatric brain tumor surgery: Optimizing surgical decision-making and extent of resection. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 63.5 23 Multiparametric flow-cytometry minimal residual disease before hematopoietic stem cell transplantation predicts outcome in pediatric acute myeloid leukemia. Haematologica 49.5 24 Vitamin D Receptor BsmI Polymorphism and Inflammatory Features in Juvenile Idiopathic Arthritis. Immunological investigations 58.5 25 Adult Pilomyxoid Astrocytoma Mimicking a Craniopharyngioma: An Unusual Suprasellar Presentation. Annals of African medicine 54.0 26 Intraoperative Evaluation of Sarcoma Surgical Margins With Indocyanine Green Fluorescence Imaging: Results From an Observational Study. Journal of surgical oncology 76.4 27 Rigorous, transparent and inconclusive: what Europe's first joint clinical assessment reveals about a framework trying to serve everyone. Journal of comparative effectiveness research 59.0 28 Effects of Olanzapine on Chemotherapy-Related Anxiety in Pediatric Cancer Patients: A Pilot Study. Pediatric blood & cancer 86.74 29 Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees. Pediatric blood & cancer 57.24 30 Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk. Pediatric blood & cancer 65.0 31 AI-Assisted Generation of Long-Term Follow-Up Recommendations for Survivors of Childhood Cancer and Hematopoietic Stem Cell Transplantation. Journal of pediatric hematology/oncology 61.9 32 The long-term follow-up outcomes and transition rates across seven representative pediatric congenital surgical conditions: disease severity drives follow-up retention. Pediatric surgery international 66.5
PATIENT-FRIENDLY SUMMARY

The origin and polarization of Macrophages and their role in the formation of the Pre-Metastatic niche in osteosarcoma.

For education only—not personal medical advice.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic