← Back to all signals
RESEARCH PAPER ANALYSIS

[Clinical efficacy and safety of CLAE regimen for refractory/relapsed T cell acute lymphoblastic leukemia/lymphoma: a prospective, multicenter, single-arm study].

AI interpretation is pending for this paper.

Open original publication →
PMID41407457
JournalZhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
Publication Date2025-11-14
Ingested2026-08-02 12:05 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

Objective: To evaluate the efficacy and safety of the CLAE (cladribine + cytarabine + etoposide) regimen in refractory/relapsed T cell acute lymphoblastic leukemia/lymphoma (R/R T-ALL/LBL) . Methods: Patients with R/R T-ALL/LBL received the CLAE regimen in a prospective, multicenter, single-arm clinical study or compassionate use. From March 2019 to August 2024, data from 25 patients (18 in the study across five centers and 7 receiving compassionate treatment in Peking University Third Hospital) were collected. Outcomes included objective response rate, complete response (CR) rate, partial response (PR) rate after 1-2 cycles, bridging to allo-HSCT, progression-free survival (PFS), overall survival (OS), and treatment-related adverse effects. Results: Median age was 29 years (range, 13-63) ; 17 were male. Among the 24 evaluable patients, CR rate was 33.3% overall and 41.2% among enrolled patients. Median OS and PFS time were 199 (46-1 310) and 49 (28-1 310) days, respectively. Cumulative OS rate at 6 months, 1 year, and 2 years was (52.1±10.2) %, (29.7±9.3) %, and (27.1±9.1) %, respectively; cumulative PFS rate was (32.6±9.6) %, (24.9±8.9) %, and (23.8±8.7) %, respectively. Among patients achieving CR or PR (8 cases), median OS and PFS were not reached. Cumulative OS rate at 6 months, 1 year, and 2 years was (86.8±12.0) %, (78.3±14.6) %, and (72.9±15.7) %, respectively, and the cumulative PFS rate was (86.4±12.1) %, (74.8±15.3) %, and (72.9±15.7) %, respectively. Adverse events were mainly hematologic; no treatment-related mortality occurred. Seven patients achieving CR were bridged to allo-HSCT, with 5 remaining in continuous remission. Conclusion: The CLAE regimen is safe and effective for R/R T-ALL/LBL, facilitating CR as a bridge to allo-HSCT and potentially improving patient prognosis.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 A Longitudinal Observational Mixed Methods Cohort Study of the Psychosocial and Financial Costs of Cancer Care for Pediatric Families in the Maritimes, Canada. Cancer control : journal of the Moffitt Cancer Center 68.1 2 Impact of multidrug resistant bloodstream infection burden, prophylactic levofloxacin and rectal swab practice on children with high-risk leukemias. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 74.66 3 Case Report: Primary Cutaneous Aspergillosis in a Neutropenic Child with Pulmonary Dissemination: A case report. F1000Research 55.5 4 NIH funding in the biophotonics community. Biophotonics discovery 57.5 5 Giant Cell Tumor of the Distal Humerus: A Rare Location With a Good Response to Denosumab. Cureus 62.42 6 Peripheral Blasts at Apheresis as a Risk Factor for Survival following Tisagenlecleucel in Children and Young Adults. Blood advances 72.82 7 Envenomation-Induced Hemophagocytic Lymphohistiocytosis (HLH): First Reported Adult Case Following A Spider Bite. European journal of case reports in internal medicine 63.5 8 Rare mandibular metastasis of neuroblastoma in a child: a case report. Frontiers in dental medicine 52.3 9 Rising burden of early-onset lung cancer among Chinese adolescents and young adults (1990-2023): a Bayesian age-period-cohort analysis with projections to 2038. Frontiers in medicine 57.5 10 Immune microenvironment of infantile hemangioma: cellular dynamics, molecular networks, and emerging immunomodulatory strategies. Frontiers in immunology 67.8 11 Intranodal palisaded myofibroblastoma of the supraclavicular region in an adolescent with an HDAC2 variant: a case report. Frontiers in medicine 45.5 12 Development and validation of a prediction model for 6-month early death in pediatric H3K27M-mutant diffuse intrinsic pontine glioma (DIPG). Translational pediatrics 66.3 13 Radiofrequency ablation for severe hemangiomas with thrombocytopenia and coagulation abnormalities (Kasabach-Merritt phenomenon). Translational pediatrics 63.6 14 Global burden and trends of tracheal, bronchus, and lung cancer in adolescents and young adults: a secondary analysis of the Global Burden of Disease Study 2021. Journal of thoracic disease 67.9 15 Molecularly guided management of pediatric endobronchial inflammatory myofibroblastic tumor: a report of two cases on surgical and targeted intervention. Translational pediatrics 64.7 16 Stage-associated differences in injury and stress responses of hiPSC-derived cardiomyocytes under macrophage-derived inflammatory stimulation. Translational pediatrics 51.62 17 Glycyrrhizin alleviates Mycoplasma pneumoniae-induced acute lung injury in mice by regulating ferroptosis via the GPX4/ACSL4 axis. Journal of thoracic disease 58.0 18 Traditional Chinese medicine combined with conventional Western medicine for chronic cough following respiratory infection in children: a systematic review and meta-analysis. Translational pediatrics 84.2 19 A taurine metabolism-related gene program defines clinical and biological features of neuroblastoma and yields an 8-gene candidate prognostic model. Translational pediatrics 58.7 20 Diagnostic and therapeutic value of double-balloon enteroscopy in pediatric patients with Peutz-Jeghers syndrome. Translational pediatrics 64.74 21 Intratumoral and peritumoral-based radiomics for assessment of lymphovascular invasion in invasive breast cancer: model development and validation. Translational cancer research 64.9 22 Development and validation of a predictive model for thyroid nodule malignancy risk based on intralesional and perilesional ultrasound radiomic features. Gland surgery 67.0 23 Advanced esophageal adenocarcinoma in a pediatric patient with Down syndrome: a rare case report and literature review. Annals of medicine and surgery (2012) 55.4 24 First case description of a highly aggressive thoracopulmonary primitive neuroectodermal tumor in a Moroccan adult male. Annals of medicine and surgery (2012) 56.7 25 DAT-negative autoimmune hemolytic anemia following acute hepatitis a in a pediatric patient with elevated IgA: a rare case report and literature review. Annals of medicine and surgery (2012) 55.0 26 Exploring New Frontiers in Osteosarcoma Treatment: Clinical Trial Insights. Recent patents on anti-cancer drug discovery 85.44 27 Pediatric low-grade glial, glioneuronal and neuronal tumors: a retrospective study of 85 cases. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 63.0 28 Outcomes of Pediatric Precursor B Cell Acute Lymphoblastic Leukemia: A Tertiary Care Cancer Center Experience from a Lower-Middle-Income Country. Journal of cancer & allied specialties 67.4 29 Long-Term Survival Patterns in Childhood B-Cell Non-Hodgkin Lymphoma in Resource-Constrained Countries. Journal of cancer & allied specialties 74.42 30 Outcomes of Methotrexate-Based Therapy for Paediatric Osteosarcoma: A Decade of Experience from a Cancer Centre in Pakistan. Journal of cancer & allied specialties 71.74 31 Late Anthracycline Cardiotoxicity Mimicking Arrhythmogenic Cardiomyopathy in a Young Adult. JACC. Case reports 55.62 32 Spontaneous complete regression of congenital brain tumors - a systematic literature review and case report. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 66.0
PATIENT-FRIENDLY SUMMARY

[Clinical efficacy and safety of CLAE regimen for refractory/relapsed T cell acute lymphoblastic leukemia/lymphoma: a prospective, multicenter, single-arm study].

For education only—not personal medical advice.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic