← Back to all signals
RESEARCH PAPER ANALYSIS

Clinical Characteristics and Prognostic Risk Factors for Pediatric B-Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma.

AI interpretation is pending for this paper.

Open original publication →
PMID41618586
JournalPediatric blood & cancer
Publication Date2026-01-30
Ingested2026-08-02 12:06 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

BACKGROUND: B-cell lymphoblastic lymphoma (B-LBL) represents a rare variety of non-Hodgkin lymphoma, with limited research on its biology, progression, and management. METHODS: A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)-NHL-2017-lymphoblastic lymphoma regimen from April 2017 to March 2023. RESULTS: Among the 256 patients, the median age at diagnosis was 5.0 years, with a slight male predominance. Subcutaneous tissues, skin, and osteolytic bone were the most common sites of the disease. More than 90% of patients exhibited disseminated disease (Stage III or IV). Approximately 19.9% of the diagnosed patients exhibited central nervous system involvement. Adverse events were observed in 33 patients (12.9%), with disease progression or relapse occurring in 10.2% of cases, particularly linked to unfavorable outcomes in instances of early relapse or progression. Salvage chemotherapy combined with immunotherapies, followed by bridging hematopoietic stem cell transplantation, significantly improved the prognosis of relapse and disease progression in children. Overall, the follow-up time was 37.6 (Q1-Q3, 28.9-38.0) months, and 3-year event-free survival rate and overall survivals were 86.3% ± 2.5% and 95.2% ± 1.5%, respectively, with a treatment-related mortality of 1.6%. Multivariate analysis showed that poor prednisone response and no complete remission on Day 33 of induction were risk factors for poor prognosis. CONCLUSION: The CNCL-NHL-2017-lymphoblastic lymphoma regimen was effective in children with B-LBL. The response to initial treatment is vital for improving prognosis in patients with B-LBL.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 The Journey with paediatric cancer: reflections on its impact on patients and their families. The Pan African medical journal 56.0 2 Pars plana vitrectomy in uveitis of diverse etiologies: indications and surgical outcomes. BMC ophthalmology 63.5 3 Persistent Oropharyngeal Hemangioma Causing Progressive Upper Airway Compromise: Diagnostic and Therapeutic Challenges. Cureus 61.64 4 Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment, and follow-up of patients with hepatocellular carcinoma. ESMO open 71.84 5 Life Saving Hepatic Resections in Ruptured Pediatric Hepatoblastoma - a Report of 3 Cases. Indian journal of surgical oncology 63.6 6 Development and Internal Validation of the SPR-HCC Score System: A Prognostic Tool for Survival Prediction in Hepatocellular Carcinoma in a Resource-Limited Setting. Asian Pacific journal of cancer prevention : APJCP 72.02 7 Retinoblastoma Incidence in Saudi Arabia: A 20-Year Analysis. Asian Pacific journal of cancer prevention : APJCP 57.5 8 Systemic Immune Inflammation Index as High-Risk Retinoblastoma Survival Predictor. Asian Pacific journal of cancer prevention : APJCP 63.12 9 Predictors of Cervical Cancer Screening Uptake Among Women of Reproductive Age in Indonesia: A Nationwide Cross-Sectional Study Based on the 2023 Indonesian Health Survey. Asian Pacific journal of cancer prevention : APJCP 67.5 10 Effects of estetrol/drospirenone vs drospirenone-only on thrombin generation in women with polycystic ovary syndrome: a randomized, double-blind, controlled trial. Research and practice in thrombosis and haemostasis 77.6 11 Quality indicators for the care of children with CNS tumors: An international modified Delphi study. Neuro-oncology advances 72.0 12 Feasibility, uptake, and exploratory outcomes of an individualized exercise program in pediatric oncology: a prospective single-center pilot study. Frontiers in pediatrics 64.1 13 Prenatal diagnosis and outcomes of fetal cardiac tumors: a 10-year single-center study of 81 cases. Frontiers in medicine 66.0 14 Advances in the association between tumor immune microenvironment remodeling in osteosarcoma and the risk of pathological fractures. Frontiers in genetics 54.3 15 Proximal Phalanx Enchondroma in a Pediatric Patient: Curettage, Liquid Nitrogen Cryotherapy, Iliac Crest Autograft, and Microfragment Plate Fixation. Cureus 61.64 16 Beyond size: the role of growth rate in managing adolescent breast masses. American journal of surgery 68.5 17 Primary ovarian non-small cell neuroendocrine carcinoma in an adolescent: The youngest case reported to date. Pathology, research and practice 45.5 18 Indocyanine Green (ICG) fluorescence-Guided Surgery (FGS) in pediatric Wilms tumor: Opportunities and Challenges. Surgical oncology 47.5 19 Targeting SUV4-20H2-mediated H4K20 methylation restrains growth and migration in pediatric high-grade astrocytomas. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 62.2 20 Timing of breast cancer diagnosis postpartum and survival in women with germline pathogenic variants. ESMO open 71.02 21 Myxoid Pleomorphic Liposarcoma: A Clinicopathological and Cytogenomic Study of 24 Cases. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 60.7 22 Astragaloside IV is associated with TFRC-dependent ferroptosis and JAK2/STAT3 pathway inhibition in osteosarcoma cells. Biochimica et biophysica acta. General subjects 68.5 23 Purely osteolytic bone lesions in the early osteoarticular phase of synovitis, acne, pustulosis, hyperostosis and osteitis syndrome. BMJ case reports 54.0 24 Spatial Lineage Divergence at Diagnosis in a Pediatric KMT2A-Rearranged Leukemia Presenting with Concurrent AML and B-LBL. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 53.9 25 Temporary Perineal Urethrostomy for Bladder Tumor Resection. Case reports in urology 45.5 26 Public support for policies to create a healthier food environment in Aotearoa New Zealand: findings from a national survey. The New Zealand medical journal 65.2 27 The public in Aotearoa New Zealand support policies to reduce alcohol harm: results from a national survey. The New Zealand medical journal 66.5 28 Public support for government-led skin cancer prevention in Aotearoa New Zealand: findings from a national survey. The New Zealand medical journal 66.6 29 Public support for better controls on lobbying and industry influence in Aotearoa New Zealand: findings from a national survey. The New Zealand medical journal 43.2 30 Aotearoa New Zealanders' views of policies and funding for human papillomavirus vaccination and screening for cervical and lung cancers: a national survey. The New Zealand medical journal 66.4 31 Aotearoa New Zealand public strongly support investment in cancer treatment and care services: findings from a national survey. The New Zealand medical journal 66.94 32 Public support for cancer prevention and care policies in Aotearoa New Zealand: methods of a national survey. The New Zealand medical journal 66.9
PATIENT-FRIENDLY SUMMARY

Clinical Characteristics and Prognostic Risk Factors for Pediatric B-Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma.

For education only—not personal medical advice.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic