← Back to all signals
RESEARCH PAPER ANALYSIS

Advanced diffusion MRI tractography for radiotherapy planning in pediatric brain tumors: A feasibility study.

AI interpretation is pending for this paper.

Open original publication →
PMID41704949
JournalPhysics and imaging in radiation oncology
Publication Date2026-02-02
Ingested2026-08-02 12:06 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

BACKGROUND AND PURPOSE: Cranial radiotherapy for pediatric brain tumors can damage white matter tracts (WMTs), adversely impacting brain development. This study evaluated the feasibility of integrating advanced diffusion MRI (dMRI) tractography-derived WMTs into radiotherapy planning for pediatric supratentorial high-grade tumors. MATERIALS AND METHODS: The study retrospectively recruited eight patients (aged 8-16 years) who had undergone surgery and curative-intent radiotherapy from January 2012 to June 2022. The pre-radiotherapy dMRI was utilized to reconstruct the target and 29 individual WMT masks selected based on their relevance to neurocognition, motor, language, and visual functions. These WMT masks were classified into five distance-based priority groups based on their proximity to the tumor, and were subsequently used to re-optimize radiotherapy plans. The dose-volume metrics of the tract-optimized plans were compared to the standard treated plans using the Wilcoxon signed-rank test. RESULTS: In all cases, the tract-optimized plans achieved a significant dose reduction to the normal brain compared with standard plans across various dose levels (Dmean, D10%, D20%, D50%) by 2.3-3.5 Gy (p < 0.01), equivalent to 5% of the prescription dose. Dmean was reduced for all five WMT groups (p < 0.05), ranging from 3.5-6 Gy, depending on proximity to target, whilst target coverage was maintained (p > 0.05). A Dmean reduction of approximately 1 Gy was achieved to ipsilateral (p < 0.05) and contralateral (p < 0.01) temporal lobes. CONCLUSION: Integrating advanced dMRI tractography into radiotherapy plan can enable functional sparing of critical WMTs without compromising target coverage for pediatric supratentorial high-grade brain tumors.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Single-session therapeutic plasma exchange as salvage therapy for pegaspargase-induced severe acute pancreatitis accompanied by multiple organ dysfunction in a pediatric patient with B-cell precursor acute lymphoblastic leukemia: a case report. BMC pediatrics 67.0 2 Evaluation of Regulatory B10 Cells in Common Variable Immunodeficiency Patients with and without Autoimmunity. Iranian journal of allergy, asthma, and immunology 59.1 3 An Unexpected Association of a Novel MYOF Variant with Generalized Myopathy and HAE-nl-C1-INH. Iranian journal of allergy, asthma, and immunology 38.6 4 Case Report: CBFA2T3::GLIS2-positive myeloid sarcoma with focal bone marrow involvement mimicking Ewing sarcoma in an infant. Frontiers in oncology 56.6 5 Extended genotype-phenotype spectrum of 17α-hydroxylase/17,20-lyase deficiency: a nine-case series featuring a novel mutation, suspected TART-like lesions, and multisystem involvement. Frontiers in endocrinology 54.5 6 Reninoma in an adolescent boy with negative selective renal vein sampling: a case report and review of the literature. Frontiers in endocrinology 50.3 7 Precision-based exercise protocols for children with cancer: a methodological approach from the European FORTEe research project. Frontiers in pediatrics 76.6 8 CircHIPK3 promotes the progression of B-cell acute lymphoblastic leukemia in children by binding to STAT3. Frontiers in pharmacology 54.3 9 Disease-specific heterogeneity of C-reactive protein across 21 hematologic disorders reflects divergent inflammatory and hematopoietic phenotypes. Frontiers in immunology 76.0 10 Exercise intervention for children with acute leukemia: a best evidence summary. Frontiers in pediatrics 82.2 11 Oral and maxillofacial malignancies in children and adolescents: a 17-year single-center retrospective study. World journal of pediatric surgery 66.9 12 Adult Recurrent Wilms' Tumor Presenting as a Large Mass: A Case Report and Current Literature Review. Sisli Etfal Hastanesi tip bulteni 56.7 13 Exploring beyond the typical Wilms tumor: What a radiologist needs to know. Current problems in diagnostic radiology 60.4 14 The association between the oral microbiome and oral Kaposi's sarcoma-associated herpesvirus (KSHV) shedding is modified by age and HIV status in a rural Ugandan cohort. Journal of oral microbiology 58.0 15 Diagnostic Accuracy and Predictive Factors of Sentinel Lymph Node Biopsy in Cutaneous Squamous Cell Carcinoma: A Systematic Review. Plastic surgery (Oakville, Ont.) 74.5 16 Expanding the Molecular Data of DICER1-Related Tumor Predisposition: Novel Germline Variants in an Argentine Pediatric Cohort. Human mutation 58.0 17 Epidemiology and neurological profiling of vertebral tumors in Mexico: a five-year review from a tertiary referral center. Spinal cord series and cases 63.0 18 A comparison of a novel neuropsychological screening tool with provider recommendations among pediatric cancer survivors. Journal of cancer survivorship : research and practice 61.5 19 Environmental Asbestos Exposure as a Possible Pathway to Early-Onset Pleural Mesothelioma: A Case From Afghanistan and Pakistan to London. Respirology case reports 45.5 20 Clinical consensus guidelines for the management of Noonan syndrome in Japan. Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology 74.6 21 Radioiodine or thyroidectomy in children and adolescents with Graves' disease: a structured literature review of efficacy and safety. Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology 74.6 22 Genomic characterization of carbapenem-resistant organisms from pediatric patients with hematological malignancies and genomic comparison of infection versus intestinal colonizing strains. Microbiology spectrum 62.9 23 Digital symptom monitoring in cancer care: an exploratory evaluation of low uptake and engagement. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 58.4 24 Baricitinib Efficacy Through 4 Years in Responders and Safety up to 5 Years in Adults with Severe Alopecia Areata: Final Results from BRAVE-AA1 and BRAVE-AA2. Dermatology and therapy 74.5 25 Sociodemographic correlates of human papilloma virus (HPV) and cervical cancer knowledge among Saudi women: A nationwide assessment. Medicine 59.5 26 Bibliometric mapping of the 100 most-cited publications on optic nerve and optic pathway glioma: A cross-sectional bibliometric analysis. Medicine 63.4 27 Double-balloon enteroscopy in different age groups: indications, findings, diagnosis, and treatment: A 17-year single-center retrospective cohort study. Medicine 75.14 28 Androgen insensitivity syndrome: A case report. Medicine 55.8 29 Clinical Practice Guideline for Systemic Antibacterial and Antifungal Prophylaxis in Pediatric Patients With Cancer and Hematopoietic Cell Transplant Recipients: 2026 Update. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 72.8 30 Small cell carcinoma arising in a defunctionalized bladder after urinary diversion for a benign condition: A case report and literature review. Urology case reports 49.9 31 When Diagnosis Is Not Enough: Management Challenges and Outcomes of CNS Tumours in Children Under Three Years in the Largest Public-Sector Center in Pakistan. JPMA. The Journal of the Pakistan Medical Association 69.5 32 Endoscopic Endonasal Versus Endoscopic Supraorbital Keyhole Surgery for Craniopharyngioma Resection: A 15-Year Single-Center Retrospective Cohort Study. JPMA. The Journal of the Pakistan Medical Association 66.0
PATIENT-FRIENDLY SUMMARY

Advanced diffusion MRI tractography for radiotherapy planning in pediatric brain tumors: A feasibility study.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic