← Back to all signals
RESEARCH PAPER ANALYSIS

A prospective cohort study of the factors associated with recurrence in young patients with thyroid cancer.

AI interpretation is pending for this paper.

Open original publication →
PMID41958867
JournalJournal of the Endocrine Society
Publication Date2026-03-25
Ingested2026-08-02 12:06 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

CONTEXT: The incidence of thyroid cancer in young people has increased over the past 40 years. While prognosis is favorable, recurrence rates may reach 20%. We previously reported the pathological characteristics of 220 young patients with thyroid cancer; here, we evaluated their long-term outcomes and recurrence risk. OBJECTIVE: To identify predictors of recurrence in pediatric and adolescent thyroid cancer. DESIGN SETTING AND PATIENTS: A prospective cohort of 213 patients aged 5-19 years who underwent initial surgery at Fukushima Medical University Hospital between 2012 and 2020. MAIN OUTCOME MEASURES: Recurrence was defined as cytological evidence of cancer in the thyroid remnant or lymph nodes after initial surgery or the appearance of new tumor lesions on imaging of other organs after surgery. RESULTS: Seventeen of 213 patients (8.0%) experienced recurrence during a median follow-up of 8 years. In the overall cohort, younger age was the strongest predictor of recurrence, particularly in patients younger than 15 years. Other pathological features such as lymph node metastasis and pathological intra-thyroidal dissemination (ITD) showed associations in univariate analysis but lost significance after adjustment for age. CONCLUSION: Unilateral lobectomy was not associated with an increased risk of recurrence. Recurrence was most frequent in patients <15 years and occurred more often in those with multifocal disease, advanced stage, N1b nodes, or ITD. These findings provide clinically relevant prognostic insights that may help refine clinical management in young patients with thyroid cancer.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Men's Self-Reported Knowledge and Awareness Towards Male Breast Cancer in Saudi Arabia: A Cross-Sectional Study. Cancer control : journal of the Moffitt Cancer Center 65.2 2 Deep learning-based automated segmentation of target volumes for pediatric craniospinal irradiation in proton therapy. Radiation oncology (London, England) 60.74 3 Fertility-related distress and female identity reconstruction among reproductive-age women with breast cancer in China: a qualitative study. BMC women's health 61.9 4 Awake craniotomy for drug-resistant non-oncological epilepsy: a systematic review of feasibility, reported safety, and seizure outcomes. BMC surgery 77.06 5 Exosomal microRNAs in tumor-heart crosstalk: nanobiological mechanisms and therapeutic implications. Journal of nanobiotechnology 71.09 6 Quantifying the social net: a nomogram to predict baseline quality of life at clinical entry for head and neck cancer. World journal of surgical oncology 65.7 7 A comprehensive assessment of cervical cancer risk factors, screening modalities, and cytological outcomes. JPMA. The Journal of the Pakistan Medical Association 57.5 8 Location Matters: Expanding Advanced Practice Provider Roles to Increase Access to Specialized Adolescent and Young Adult Oncology Care. Journal of the advanced practitioner in oncology 64.0 9 Risk factors and predictive value of lung ultrasound aeration score for postoperative pulmonary complications in pediatric patients undergoing abdominal tumor resection: a prospective observational study. BMC anesthesiology 57.5 10 Clinical outcomes of T-cell acute lymphoblastic leukemia versus T-cell lymphoblastic lymphoma after allogeneic hematopoietic stem cell transplantation. Annals of hematology 65.5 11 [A Multicenter Retrospective Investigation of the Distribution of High-Risk HPV Genotypes Among Women Who Underwent HPV Testing in Azerbaijan]. Mikrobiyoloji bulteni 57.5 12 Frequency of Thiopurine S-methyltransferase (TPMT) Genotypes Among Patients With Acute Lymphoblastic Leukemia at a Tertiary Care Hospital in Bangladesh: A Cross-Sectional Study. Cureus 66.2 13 Temporary arterial clamping in major musculoskeletal malignant tumour surgery: A two-centre comparative study. Cardiovascular journal of Africa 59.5 14 Hilar cysts in jaundiced neonates: Diagnostic challenges and surgical outcomes at a National Pediatric Referral Center in Colombia. Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica 58.9 15 Endoscopic cryoprobes in the pediatric airway: Initial experience. Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica 65.6 16 [Analysis of influencing factors for the occurrence of transient hypernatremia in patients with extremely severe burns]. Zhonghua shao shang yu chuang mian xiu fu za zhi 76.8 17 Fear of cancer recurrence in caregivers of paediatric cancer survivors in Singapore. Annals of the Academy of Medicine, Singapore 47.5 18 The feasibility of training nnU-Net to segment pediatric Wilms tumor with small datasets. Frontiers in oncology 66.0 19 Risk factors for persistent high-risk HPV infection and recurrence burden of vaginal infections in women with cervical low-grade squamous intraepithelial lesions: a retrospective cohort study. Frontiers in cellular and infection microbiology 70.0 20 DeepOSSA: a deep learning framework for personalized survival prediction in osteosarcoma patients. Frontiers in cell and developmental biology 62.72 21 Case Report: Diagnostic and management challenges of necrotizing fasciitis in an immunocompromised child with acute lymphoblastic leukaemia. Frontiers in surgery 54.6 22 Juvenile xanthogranuloma mimicking malignancy at uncommon sites in children: five cases and a systematic review. Frontiers in oncology 71.5 23 Human Gut Microbiota of Healthy Individuals Show Resilience to Acute Aflatoxin B1 Exposure Despite Solvent-Driven Community Shifts. bioRxiv : the preprint server for biology 43.9 24 First-in-human quad-targeting CAR T cells for diffuse intrinsic pontine glioma: a phase 1 trial. Research square 79.4 25 Lineage-mixed neurodevelopmental programs in pediatric sarcomas nominate tumor-selective surface antigen pairs. bioRxiv : the preprint server for biology 54.1 26 PedDx: An End-to-End Deep Learning Framework for Pediatric Posterior Fossa Tumor Diagnosis with Agentic AI-Enabled Independent External Evaluation. medRxiv : the preprint server for health sciences 61.0 27 Reproductive Choices and Family-building Decision Uncertainty Among Young Women at Familial Risk for Breast Cancer. Research square 66.0 28 Solitary Neurofibroma in the Submental Region of a 15-Year-Old Adolescent: A Case Report and Review of Literature. International medical case reports journal 49.9 29 Lifetime Hormonal Exposure and Risk of Lung Cancer in Women: Results From a French Population-Based Case-Control Study (The WELCA Study). Cancer medicine 69.0 30 Histotripsy for Hepatocellular Carcinoma in Asia-Pacific: Current Evidence, Evidence Gaps, and Future Research Priorities. Journal of hepatocellular carcinoma 71.6 31 ISR addiction: Co-opting a stress sentinel to fuel tumor resilience and therapy resistance. Neoplasia (New York, N.Y.) 68.84 32 Late Presentation of Fetus in Fetu in a 10-Year-Old Boy. Case reports in pediatrics 38.5
PATIENT-FRIENDLY SUMMARY

A prospective cohort study of the factors associated with recurrence in young patients with thyroid cancer.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic