Pineal Tumours: Results, Follow-Up and Sequelae in Children and Adults According to the French Registry of Pineal Tumours and the Lyonnais Registry.
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INTRODUCTION: Pineal tumours remain a challenging pathology, even in the era of molecular classification. The different types of pineal gland tumours require tailored management strategies, determined through a multidisciplinary approach. In this chapter, we present data from the French registry on the management of pineal region tumours in both paediatric and adult populations, with a particular emphasis on differences observed in the Lyon experience. COHORT AND METHOD OF THE DATA ANALYSIS: To ensure uniformity in histological analysis, registry data were reviewed for the period between 1997 and 2022. Consequently, 689 patients from the national registry and 292 from the Lyon series were eligible for inclusion. Clinical and survival analyses were performed, evaluating demographic and clinical data, tumour histology, type of surgery and/or adjuvant treatment, complications and follow-up. Each topic is described in a separate chapter, with data on pineal region tumours analysed and discussed according to histological subtype. CONCLUSION: The treatment of pineal region tumours remains challenging and their prognosis is still poor. In the future, the advances in genetics and molecular biology could allow more patients to be cured with better tailored treatments. For rare tumours, there is a clear need for structural databases that enable comprehensive evaluation of pineal pathology, encompassing all modern aspects: from clinical presentation to tumour genetics. Continuous input into this registry is therefore essential to enhance our understanding of this group of tumours and to improve the efficacy of management by reducing treatment-related morbidity and the mortality.