← Back to all signals
RESEARCH PAPER ANALYSIS

18 F-FDG PET/CT Derived Volumetric Parameters Can Predict Outcome in Pediatric Ewing Sarcoma.

AI interpretation is pending for this paper.

Open original publication →
PMID42165931
JournalAnnals of nuclear medicine
Publication Date2026-05-21
Ingested2026-08-02 12:06 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

OBJECTIVE: To evaluate the prognostic and predictive value of metabolic and volumetric parameters obtained from baseline (PET1) and post-chemotherapy (PET2) 18 F-FDG PET/CT in pediatric Ewing sarcoma (EWS) patients, focusing on their associations with histopathologic response, metastatic presentation, overall survival (OS), and progression-free survival (PFS). METHODS: This retrospective single tertiary academic center study included 55 pediatric EWS patients who underwent PET1. Twenty-four patients also had PET2. SUVmax, SUVpeak, metabolic tumor volume (MTV), total lesion glycolysis (TLG) and their percentage changes (∆) between PET scans were calculated using absolute (SUV 2.0 and 2.5) and relative (40% and 45%) thresholds. Anatomic tumor volume was also measured. Histopathologic evaluation was available for 40 patients with PET1 and 18 patients with PET2. Associations were analyzed using logistic and Cox regression models. RESULTS: Baseline metabolic and volumetric PET parameters were significantly higher in patients with presenting metastasis. Among these, TLG (45%) was identified as the only independent predictor of metastatic presentation (OR = 1.026, p = 0.019). Baseline MTV (2.0) was independently associated with shorter OS (HR = 1.026, p = 0.003) and PFS (HR = 1.035, p = 0.038). Combined stratification using MTV (2.0) and histologic response revealed that patients with an unfavorable histologic response but low MTV demonstrated superior OS and PFS rates than those with an unfavorable response and high MTV. The survival outcomes of patients with a favorable histologic response and high MTV were comparable to those with an unfavorable response and low MTV. However, PET parameters did not reliably predict histopathologic response in this cohort. CONCLUSIONS: Baseline MTV (2.0) demonstrated prognostic value for OS and PFS, while TLG (45%) independently predicted metastatic presentation in pediatric EWS. The combination of MTV (2.0) and histologic response appears to provide complementary prognostic information. Prospective, multicenter studies with standardized imaging and treatment protocols are warranted to validate the role of volumetric 18 F-FDG PET parameters in clinical risk stratification.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Inverted Meckel's diverticulum in adults: two case reports and a systematic review. BMC gastroenterology 73.9 2 Torsion and infarction of a large pediatric mesenteric inflammatory myofibroblastic tumor: a case report. Journal of medical case reports 47.5 3 Preoperative Chemotherapy and Its Efficacy in Pediatric Wilms Tumor: A Systematic Review of Randomized Controlled Trials. Cureus 84.94 4 Fear of disease progression in primary caregivers of children with malignant solid tumors: a latent profile analysis. BMC psychology 66.9 5 Protracted copy number alteration evolution in Barrett's oesophagus leading to oesophageal cancer. medRxiv : the preprint server for health sciences 56.0 6 Editorial: The expanding spectrum of hemophagocytic lymphohistiocytosis: pathogenic mechanisms and therapeutic implications. Frontiers in immunology 33.09 7 DNA methylation profiling reveals novel rhabdomyosarcoma subsets with distinct histologic, genetic and clinical properties. medRxiv : the preprint server for health sciences 57.5 8 Brain microvascular endothelial cell dysfunction during Plasmodium infection does not result from astrocyte-derived wingless-related integration site (Wnt)7a deficiency. bioRxiv : the preprint server for biology 50.9 9 The role of microRNAs in neuroblastoma cell differentiation and their therapeutic potential: a systematic review. Frontiers in oncology 79.54 10 Temporal clinical trajectories and Day+14 landmark stratification of infection risk after CD19 CAR T-cell therapy. Frontiers in cellular and infection microbiology 71.52 11 Co-creating the EndoWatch - a smart wearable device for the management of hypothalamic dysfunction in pediatric brain tumor survivors: a pilot study. Frontiers in endocrinology 69.4 12 Ginsenoside RK3 suppresses osteosarcoma via PRMT5/GPX4-ferroptosis axis and enhances doxorubicin chemosensitivity. Frontiers in pharmacology 59.5 13 Age-dependent differences in SARS-CoV-2 entry-factor expression and innate immune responses between pediatric and adult liver organoids. Frontiers in public health 52.62 14 Health beliefs and parental responses to human papillomavirus vaccination in the Middle East: a theory-informed narrative synthesis guided by the health belief model. Frontiers in public health 81.12 15 Diagnostic potential of Aldo-keto reductase 1B10 in pediatric hepatic malignancies: a narrative, hypothesis-generating translational review based on adult evidence and future research directions. Frontiers in medicine 60.5 16 Mucormycosis beyond the classic host: a case series and narrative literature review from a tertiary Greek hospital. Frontiers in fungal biology 60.5 17 Incidence and mortality of breast cancer among adolescent and young adult women worldwide in 2022 and projections for 2040: Implications for surgery. Breast (Edinburgh, Scotland) 57.5 18 Dynamic Radiologic Severity Index is associated with antifungal treatment but does not independently predict initiation in pediatric acute lymphoblastic leukemia with post-chemotherapy pneumonia. Translational pediatrics 75.18 19 Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE)-like spectrum with a unique NRAS c.182A>G (p.Q61R) variant: a case report. Translational pediatrics 55.2 20 Predictive value of novel inflammatory markers for post-infectious pulmonary embolism in children. Translational pediatrics 61.2 21 Persistent cerebrospinal fluid tumor cells during transient radiographic response in bilateral retinoblastoma with central nervous system involvement: a pediatric case report. Translational pediatrics 57.42 22 Risk-adapted radiotherapy in pediatric neuroblastoma: current evidence, controversies, and future directions-a narrative review. Translational pediatrics 70.44 23 Identification of amino acid metabolism-based molecular subtypes and prognostic signature to predict immune landscape and guide clinical drug treatment in osteosarcoma. Translational pediatrics 74.9 24 Hepatic arterial infusion chemotherapy in combination with immune checkpoint inhibitors and targeted therapy for advanced intrahepatic cholangiocarcinoma. Journal of gastrointestinal oncology 77.18 25 Early on-treatment alpha-fetoprotein and des-gamma-carboxy prothrombin responses are associated with outcomes in unresectable hepatocellular carcinoma receiving transarterial chemoembolization, tyrosine kinase inhibitors and programmed cell death protein-1 inhibitors. Journal of gastrointestinal oncology 75.22 26 Nephrogenic adenoma of the bladder: a case report and review of the literature. Translational andrology and urology 53.4 27 Congenital adrenal hyperplasia combined with a huge adrenal myelolipoma of the unilateral adrenal gland in a 51-year-old female: a case report. Translational andrology and urology 54.3 28 Clinicogenomic characterization and targeted therapy efficacy in Chinese patients with NTRK fusion-positive thyroid cancer: a preliminary retrospective cohort study. Translational cancer research 81.02 29 Real-world efficacy and safety of blinatumomab across three clinical settings in pediatric B-cell acute lymphoblastic leukemia: a single-center retrospective cohort study. Translational cancer research 78.4 30 Telangiectatic Osteosarcoma Arising in a Treated Unicameral Bone Cyst of the Proximal Humerus: A Case Report. Journal of orthopaedic case reports 52.3 31 Multimodal Management of an Aggressive Vertebral Hemangioma in a Child with Neurological Deficit: A Case Report with 5-Year Follow-Up. Journal of orthopaedic case reports 57.0 32 Chernobyl Papillary Thyroid Carcinoma Reveals a Complex Interplay between Environmental Exposures and Lead Genetic Variants Predisposing to Thyroid Cancer. Environmental health perspectives 68.7
PATIENT-FRIENDLY SUMMARY

18 F-FDG PET/CT Derived Volumetric Parameters Can Predict Outcome in Pediatric Ewing Sarcoma.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic