← Back to all signals
RESEARCH PAPER ANALYSIS

Feasibility and Effectiveness of CALGB 10403 Protocol in Adolescent and Young Adult Patients with Acute Lymphoblastic Leukemia/ Lymphoblastic Lymphoma: A Study at Seyed Al-Shohada Hospital, Isfahan, Iran.

AI interpretation is pending for this paper.

Open original publication →
PMID42272603
JournalInternational journal of hematology-oncology and stem cell research
Publication Date2026-01-01
Ingested2026-08-02 12:06 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

Background: Acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) are rare blood cancers with poorer survival in adolescents and young adults (AYAs) than in children. Pediatric-inspired regimens like CALGB 10403 have improved outcomes in AYAs. This study evaluated the effectiveness, feasibility, and treatment-related toxicities of CALGB 10403 in AYAs with ALL/LBL treated at Seyed Al-Shohada Hospital, Isfahan, Iran, from December 2021 to May 2024 Materials and Methods: AYAs aged 17-39 with newly diagnosed ALL/LBL (excluding Burkitt, Ph+, and prior treatment) were included. Baseline characteristics and outcomes of interest (induction response, event-free and overall survivals) were collected. Induction response was assessed via bone marrow (ALL) or CT scan/biopsy (LBL). Minimal residual disease (MRD) was evaluated by flow cytometry. Treatment-related toxicities were monitored and graded per CTCAE criteria. The feasibility of implementing the CALGB 10403 protocol was evaluated by measuring treatment delays. Results: Seventeen AYA patients with newly diagnosed ALL/LBL (median age 21) were enrolled, mostly male (14/17). Fourteen had ALL, and three had LBL. Extramedullary involvement was seen in 29%, including lymphadenopathy, bulky mediastinal masses, and CNS involvement. Sixteen patients (94%) achieved remission, with no deaths during the induction course. One-year EFS and OS were 77% and 100%, respectively. Common toxicities included hyperbilirubinemia, elevated transaminases, and infections. Treatment delays, mainly from non-adherence, occurred in 53%. Eight patients achieved MRD negativity after Course I. Conclusion: This study provides insights into the first Iranian experience with the CALGB 10403 protocol for AYAs with ALL/LBL, a regimen that has demonstrated encouraging survival outcomes in U.S. trials.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Serological Evaluation of Anti- FSH Antibody and Anti- LH antibody In Iraqi Women with Polycystic Ovarian Syndrome. F1000Research 62.66 2 Deaths: Leading Causes for 2024. National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System 57.5 3 Association between hematopoietic recovery indicators and minimal residual disease after induction therapy in newly diagnosed pediatric acute myeloid leukemia. Frontiers in medicine 64.74 4 Methylprednisolone sodium succinate combined with azithromycin in the treatment of Mycoplasma pneumonia in children and Its effect on immune function. Frontiers in pediatrics 67.54 5 Potential of isotoxic dose escalation with robustly optimized VMAT and IMPT for large hepatocellular carcinoma according to baseline liver function. Journal of applied clinical medical physics 80.42 6 Lifestyle Behaviors and Physical Health in Canadian Childhood, Adolescent, and Young Adult Cancer Survivors. Cancer medicine 58.7 7 Assessment of Selected Immunophenotypic Markers in Childhood Non-Hodgkin's Lymphomas in Ghana: A Possible Tool for Effective Stratification of Patients and Assessment of Survival Outcomes. Cancer reports (Hoboken, N.J.) 70.02 8 Establishing environmental causes of childhood cancer: a view from the IARC Monographs. UCL open. Environment 63.0 9 Chatbot Intervention and Cancer Risk Knowledge in Adolescents and Young Adults With Cancer Predisposition: A Randomized Clinical Trial. JAMA network open 73.7 10 Qualitative Exploration of Fertility-Related Attitudes and Perspectives Among Young Adult Women Diagnosed With Breast Cancer at Periurban Cancer Center in Uganda. JCO global oncology 61.1 11 Rare aetiologies of leg ulcers: a prospective analysis. Journal of wound care 65.8 12 Clinically actionable genetic findings by exome sequencing performed for therapeutic purposes in children with very-high risk cancer included the MAPPYACTS study. European journal of cancer (Oxford, England : 1990) 71.54 13 Rapid Whole Genome Sequencing Enhances Pediatric Cancer Diagnosis. Nature communications 66.6 14 Cardiopulmonary exercise testing to measure cardiorespiratory fitness in childhood cancer survivors. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 47.5 15 Age- and latency-specific patterns of subsequent malignant brain and other nervous system tumors after cancer diagnosed before age 40 years. Cancer causes & control : CCC 56.0 16 Impact of Extent of Surgical Resection on Survival in Patients With High-risk Neuroblastoma: A Report From Children's Oncology Group ANBL0532. Annals of surgery 71.72 17 Routine Serologic Duffy Testing in Pediatric Oncology: Clinical Utility and Feasibility in a Single-Center Cohort. Pediatric blood & cancer 79.0 18 Exercise Capacity, Physical Activity, Fatigue, and Neurocognitive Function in Adult Survivors of Childhood Acute Lymphoblastic Leukemia. Pediatric blood & cancer 61.0 19 "We Cannot Talk as a Family": Complexities of Survivorship Communication Among Hispanic/Latino Young Adult Survivors of Childhood Cancer, Parents, and Clinicians. Pediatric blood & cancer 59.6 20 Textbook Outcome in Pediatric Nephroblastoma Surgery After Neoadjuvant Chemotherapy: Defining Standards, Introducing Near-Miss, and Predictors of Failure. Pediatric blood & cancer 73.54 21 Parents of Youth With Cancer Report on Their Psychosocial Care: iSTEPPP Survey Finds Alignment and Gaps With Standards. Pediatric blood & cancer 61.9 22 Skipping of Exon 38 in Neurofibromatosis Type 1 Gene Is Not a Pathogenic Variant. Pediatric blood & cancer 54.0 23 Evidence-Based Clinical Practice Guidelines for the Management of Pediatric Febrile Neutropenia: Resource-Sensitive Recommendations for the Asian Continent. Pediatric blood & cancer 67.4 24 Obesity's Impact on Prognosis in Ph-Like Acute Lymphoblastic Leukemia. Pediatric blood & cancer 61.2 25 Occupation and Lymphoma Risk by Cell of Origin: A Nationwide Matched Case-Control Study in Thailand. Cancer prevention research (Philadelphia, Pa.) 69.0 26 Cardioneuromodulation for Recurrent Malignant Neurocardiogenic Syncope in Pediatric Patients: Results from a Tertiary Center. Pediatric cardiology 61.5 27 Invasive Pneumococcal Disease in Children: A Retrospective Three-Center Study in Zhejiang Province, China (2010-2024). Infectious diseases and therapy 66.1 28 Speciation-informed Bayesian assessment of metal(loid) exposure from Akora River fish, Ghana, for consumption guidance. Environmental monitoring and assessment 58.4 29 Clinical characteristics, anatomical distribution, and diagnostic patterns of simple bone cysts in Japan: an analysis of the Japanese Bone and Soft Tissue Tumor registry. International journal of clinical oncology 66.9 30 Pathological fracture as initial manifestation of malignancy and survival based on diagnoses: a register-based cohort study from the Swedish Fracture Register and the Swedish Cancer Register. Acta orthopaedica 66.52 31 Melanoma Prevention Among Children of Melanoma Survivors: A Randomized Clinical Trial. JAMA dermatology 78.0 32 Causal estimation and machine learning methods for survival outcomes among AYA cancer patients: A scoping review. Cancer epidemiology 67.02
PATIENT-FRIENDLY SUMMARY

Feasibility and Effectiveness of CALGB 10403 Protocol in Adolescent and Young Adult Patients with Acute Lymphoblastic Leukemia/ Lymphoblastic Lymphoma: A Study at Seyed Al-Shohada Hospital, Isfahan, Iran.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic