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RESEARCH PAPER ANALYSIS

Developing Tobacco Risk Communications for Young Adults Susceptible to Dual Use of Combustible Cigarettes and Nicotine Vapes: Mixed Methods Study.

This mixed-methods formative study found that young adults generally rated tobacco-risk messages about toxic constituents and cardiopulmonary harms most favorably, while comparative vaping-versus-smoking messages raised concerns about inadvertently endorsing vaping and did not consistently outperform standard messages.

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PMID42612616
JournalJMIR formative research
Publication Date2026-08-18
Ingested2026-08-20 09:15 AM
EXECUTIVE SUMMARY

What the AI sees

This mixed-methods formative study found that young adults generally rated tobacco-risk messages about toxic constituents and cardiopulmonary harms most favorably, while comparative vaping-versus-smoking messages raised concerns about inadvertently endorsing vaping and did not consistently outperform standard messages.

WHY IT MATTERS

Research significance

Evidence: comparative messages had higher perceived effectiveness for smoking among participants engaged in dual use than regulatory messages, but did not significantly outperform standard framing, and quitting-all-products messages were rated most effective. Inference: carefully designed communications combining novel risk information with cessation-focused efficacy language might reduce tobacco exposure and thereby contribute to long-term cancer prevention, but this study did not measure behavior change, cancer incidence, or pediatric-oncology outcomes.

ABSTRACT

Source abstract

BACKGROUND: Dual use of combustible cigarettes and nicotine vapes is disproportionately high among lesbian, gay, bisexual, transgender, and queer (LGBTQ+) young adults. Mass-reach health communications may be effective at curbing dual use. Current research is exploring whether comparative risk messaging, which presents nicotine vapes as less harmful than cigarettes, reduces dual use. OBJECTIVE: This formative message testing study focused on communicating the health risks of cigarette smoking and nicotine vaping use to young adults susceptible to dual use of these products, including LGBTQ+ young adults. METHODS: Online focus groups were conducted with young adults to develop candidate messages (N=12). Interviews (N=13) qualitatively explored thematic content. An online rating survey (N=286) quantitatively assessed perceived message effectiveness (PME) of and reactance to candidate messages applying standard and comparative risk message framing, compared to adapted regulatory warnings used by the US Food and Drug Administration. RESULTS: Qualitatively, interview and focus group participants found messages featuring novel information, including toxic constituents and physical harms (eg, hypertension), most effective. "Known" harms (eg, cancer) were described as effective by LGBTQ+ young adults due to the "shock value" of fear appeals. However, participants recommended pairing "known" harms with novel information; for example, addiction messaging was best received when described in the context of social or occasional use. Comparative messaging was appealing for harm reduction (ie, encouraging young adults who use cigarettes to quit smoking and use nicotine vapes), especially among LGBTQ+ participants. However, participants were concerned that comparative messages could unintentionally promote vaping among nicotine-naïve young adults. Qualitative participants preferred gain-framed efficacy messages that encouraged rather than demanded behavior change. Efficacy messages that emphasized "switching" were described as permissive for vaping, and participants were concerned that these may encourage sustained nicotine use. Some questioned whether vaping could effectively help young adults quit smoking. Survey results supported qualitative findings: messages with highest PME scores addressed toxic constituents, heart and lung disease, and cancer. Addiction messages were least effective. Among participants engaged in dual use, PME-smoking scores were higher when viewing candidate comparative messages than regulatory messages, but there were no significant differences between standard and comparative messages. The most effective candidate efficacy messages addressed quitting all smoking and vaping to reduce health risks. Messages that encouraged quitting smoking and switching to vapes were rated least effective. CONCLUSIONS: Comparative messaging was associated with higher PME-smoking among young adults engaged in dual use but did not consistently outperform standard messaging. Qualitative findings suggest that comparative framing may be misinterpreted as endorsing vaping as "safe" rather than "lower harm than cigarettes." Further research is needed to examine potential unintended consequences of comparative messaging, including sustained nicotine use among young adults who smoke or normalization of vaping among nicotine-naïve young adults.

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Brain, behavior, & immunity - health 57.5 13 Multi-tissue accumulation of potentially toxic elements and age-stratified non-carcinogenic dietary risk in fish from the Anzali Wetland, Caspian Basin. Toxicology reports 58.7 14 A novel spliceosome inhibitor triggers anti-tumor CD4+ and CD8+ T cell responses in murine models of pediatric-relevant cancer. Molecular therapy. Oncology 62.28 15 Prevalence and Associations for Use of Complementary and Alternative Medicine (CAM) Among Paediatric Cancer Patients in Norway: A Cross-Sectional Survey. Integrative cancer therapies 69.0 16 Portal cavernoma: epidemiological, clinical, etiological and outcome profiles - a 15-year retrospective study in a University Hospital in Rabat, Morocco. The Pan African medical journal 63.5 17 Artificial intelligence in Vietnamese healthcare: public awareness, demand, and willingness to pay. 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Research square 61.9 23 Synergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit. bioRxiv : the preprint server for biology 57.6 24 Clinical Presentation of, Treatment Approaches for, and the Impact of Social Determinants of Health on Pediatric Catatonia: A Structured Qualitative Synthesis and Targeted Literature Review. Cureus 66.04 25 Sequential Philadelphia-Positive Pre-B Acute Lymphoblastic Leukemia and Chronic Myeloid Leukemia With Distinct BCR::ABL1 Fusion Transcripts. Cancer reports (Hoboken, N.J.) 67.1 26 Intracranial germ cell tumours presenting with AVP deficiency and evolving panhypopituitarism: diagnostic pitfalls in early imaging and biopsy. Endocrinology, diabetes & metabolism case reports 64.0 27 A Subset of FOXO1-Fusion Negative Rhabdomyosarcoma With Round Cell (Alveolar) and "Burkitt-Like" Morphology Is Associated With High Amplification of MYCL: A Report From the Children's Oncology Group. Genes, chromosomes & cancer 57.5 28 Pediatric lynch-associated melanoma arising in ovarian teratoma: a case report. Gynecologic oncology reports 55.1 29 Case Report: Case series: growth hormone replacement for severe growth hormone deficiency during BRAF inhibitor therapy in pediatric low-grade glioma: long-term follow-up. Frontiers in endocrinology 70.3 30 Prognostic value of lymph node ratio in children with wilms tumor: a systematic review and meta-analysis. Frontiers in oncology 79.6 31 Real-world efficacy and safety of efgartigimod in patients with autoimmune encephalitis: a single-center retrospective analysiss. Frontiers in immunology 69.1 32 Combined aromatherapy and music or sound for emotional distress: a systematic review of controlled studies published between 2019 and 2026. Frontiers in psychology 84.84
PATIENT-FRIENDLY SUMMARY

Developing Tobacco Risk Communications for Young Adults Susceptible to Dual Use of Combustible Cigarettes and Nicotine Vapes: Mixed Methods Study.

For education only—not personal medical advice.

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