Pediatric-inspired therapy and blinatumomab consolidation improve outcomes in young adults with Philadelphia-like acute lymphoblastic leukemia.
This single-institution retrospective study of 140 adults with Philadelphia-like ALL reports that pediatric-inspired regimens were associated with higher complete-remission rates and lower relapse risk, while the title additionally reports improved outcomes with blinatumomab consolidation in young adults.
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This single-institution retrospective study of 140 adults with Philadelphia-like ALL reports that pediatric-inspired regimens were associated with higher complete-remission rates and lower relapse risk, while the title additionally reports improved outcomes with blinatumomab consolidation in young adults.
Research significance
The supplied record supports an observational association between pediatric-inspired therapy and improved response and relapse outcomes; it suggests, but does not establish, that adding blinatumomab consolidation may improve disease control in young adults with Ph-like ALL and requires prospective confirmation.
Source abstract
Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subtype of B-cell ALL associated with poor response to induction chemotherapy, suboptimal measurable residual disease (MRD) clearance, and inferior survival outcomes compared to non-Phlike subtypes. We retrospectively analyzed 140 consecutive adult patients with Ph-like ALL treated at our institution. The median age was 33.5 years, and the majority harbored CRLF2 rearrangements (85%). IKZF1plus deletion and JAK mutations were identified in 26% and 37% of patients, respectively. The majority (75%) received pediatric-inspired regimens (PIR), which were associated with higher complete remission (CR) rates (p=0.034), reduced risk of relapse (p.