Wound Microbes in Epidermolysis Bullosa: A Focus on Topical Strategies for Management of Pseudomonas Aeruginosa Colonization.
This review describes current and emerging topical approaches to managing Pseudomonas aeruginosa colonization or critical colonization in epidermolysis bullosa, largely extrapolating evidence from other skin conditions.
Open original publication →What the AI sees
This review describes current and emerging topical approaches to managing Pseudomonas aeruginosa colonization or critical colonization in epidermolysis bullosa, largely extrapolating evidence from other skin conditions.
Research significance
The record supports that P. aeruginosa colonization is associated with impaired wound healing and morbidity in epidermolysis bullosa; it is plausible, but not demonstrated here, that effective topical control could improve wound outcomes and potentially reduce microbe-associated cancer-promoting conditions.
Source abstract
Epidermolysis bullosa (EB) is a chronic blistering skin disease with a propensity for bacterial colonization, critical colonization and/or infection, namely with Staphylococcus aureus and Pseudomonas aeruginosa. While P. aeruginosa cutaneous and systemic infection are associated with significant morbidity in the EB population, critical colonization poses its own risks, given its impairment of wound healing and the hypothesized association of flagellated bacteria with wound-induced skin cancer. There is a paucity of published literature describing topical management of P. aeruginosa colonization/critical colonization in patients with EB. The purpose of this review is to describe current and emerging treatment modalities for the topical management of P. aeruginosa colonization/critical colonization in patients with EB, extrapolating from current evidence-based practices in other skin conditions that may be relevant to patients with EB.