← Back to all signals
RESEARCH PAPER ANALYSIS

Head-to-Head Comparison of Neuroblastoma Detection by [64Cu]GD2 PET and [123I]MIBG SPECT.

In five patients with neuroblastoma, both [64Cu]GD2 PET and [123I]MIBG SPECT detected disease, while [64Cu]GD2 PET identified additional lesions in patients with multiple metastases and produced higher SIOPEN and modified Curie scores.

Open original publication →
PMID42816124
JournalJournal of nuclear medicine : official publication, Society of Nuclear Medicine
Publication Date2026-09-30
Ingested2026-10-02 09:15 AM
EXECUTIVE SUMMARY

What the AI sees

In five patients with neuroblastoma, both [64Cu]GD2 PET and [123I]MIBG SPECT detected disease, while [64Cu]GD2 PET identified additional lesions in patients with multiple metastases and produced higher SIOPEN and modified Curie scores.

WHY IT MATTERS

Research significance

The reported evidence supports [64Cu]GD2 PET as a potential imaging method for metastatic neuroblastoma; it may also help noninvasively assess GD2-positive disease and inform selection or monitoring of GD2-targeted therapy, but that therapeutic application is an inference not tested in this study.

ABSTRACT

Source abstract

123I-labeled metaiodobenzylguanidine ([123I]MIBG) SPECT is well-established for neuroblastoma diagnostics. Nevertheless, therapies targeting GD2 on neuroblastoma gain clinical importance in standard treatment and clinical trials, which emphasizes the relevance of PET using the radiolabeled GD2 antibody [64Cu]Cu-NOTA-ch14.18/CHO ([64Cu]GD2) for noninvasive detection of GD2 expression. Here, we present an initial comparison of the diagnostic performance of [64Cu]GD2 PET and [123I]MIBG SPECT. Methods: Five patients with neuroblastoma underwent [123I]MIBG SPECT, [64Cu]GD2 PET, and MRI. The detected lesions were compared between [123I]MIBG and [64Cu]GD2 using International Society of Pediatric Oncology Europe Neuroblastoma (SIOPEN) and modified Curie scores. Results: Three patients suffered from multiple metastases, and 2 patients presented solitary lymph node metastases. Both modalities detected lesions in every patient; [64Cu]GD2 revealed additional lesions in patients with multiple metastases compared with [123I]MIBG, leading to higher SIOPEN and modified Curie scores. Conclusion: These initial data indicate the diagnostic suitability of [64Cu]GD2 for detection of neuroblastoma metastasis.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Genomic Profiling of Pediatric MPNST Reveals Candidate FGFR1 Driver and Incidental Germline BRCA2 Pathogenic Variant. Pediatrics international : official journal of the Japan Pediatric Society 47.5 2 Herpes zoster risk among female survivors of breast cancer in Japan. Breast cancer research : BCR 64.3 3 Childhood-onset parkinsonism, dystonia and severe muscle wasting in a Sudanese girl caused by a novel homozygous DnaJ heat shock protein family (heat shock protein 40) member C6 frameshift variant, with an incidental pathogenic breast cancer 1 gene secondary finding: a case report. Journal of medical case reports 49.0 4 Interaction between microvascular invasion and early recurrence of hepatocellular carcinoma in cirrhosis patients with curative liver resection: a retrospective cohort study. BMC gastroenterology 67.0 5 Clinical spectrum and risk factors for severe arrhythmias in non-surgical pediatric patients: a single-center retrospective study. Journal of cardiothoracic surgery 68.0 6 The lived experiences of reproductive-aged women with polycystic ovary syndrome: a qualitative study. BMC women's health 59.9 7 Adult Presentation of a Large Congenital Pulmonary Airway Malformation Discovered After Traumatic Rib Fractures. Cureus 56.0 8 A Glimpse into the Experience of Intraoperative Squash Smear Cytology of Pediatric Space-Occupying Lesions of the Central Nervous System: A Study from North Indian Tertiary Care Center. Journal of cytology 61.5 9 Long-term clinical outcomes in females with precocious puberty treated with gonadotropin-releasing hormone analogues. Frontiers in endocrinology 68.4 10 Prevalence and genotype distribution of human papillomavirus among 15,224 gynecological outpatients in Xuzhou, China, during 2023-2025. Frontiers in public health 59.5 11 Giant Cystic Lymphangioma of the Transverse Mesocolon in a 7-Year-Old Child: A Case Report. International medical case reports journal 47.5 12 Comparable efficacy of extraoral and intraoral photobiomodulation in preventing oral mucositis during high-dose methotrexate therapy in pediatric oncology: A single-blind randomized controlled trial. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 84.86 13 Premature treatment cessation in pediatric acute myeloid leukemia due to excessive toxicity: clinical experiences and patient outcomes - a case series. Pediatric hematology and oncology 65.06 14 Rare presentation of hydrocephalus occlusus caused by membranous obstruction of the foramina of Magendie and Luschka: a case report. Journal of surgical case reports 47.9 15 Impact of 131I-MIBG dose escalation (12 vs. 18 mCi/kg) during conditioning for autologous hematopoietic stem cell transplantation in pediatric neuroblastoma: a retrospective cohort study. European journal of pediatrics 74.42 16 Invisible Enemy: CMV Retinitis Despite Persistent Blood PCR Negativity in Pediatric AML. Turkish journal of haematology : official journal of Turkish Society of Haematology 47.5 17 A real-world multi-institution experience of standard versus alternative dosing regimens of inotuzumab ozogamicin for relapsed/refractory paediatric B-cell acute lymphoblastic leukaemia. British journal of haematology 68.04 18 Adolescent Chronic Sleep Restriction Induces a Mesolimbic Hypodopaminergic State Associated with Addiction Vulnerability. Sleep 49.7 19 Incidence of intra-axial brain metastases in Eastern Finland. Journal of neuro-oncology 69.0 20 Ciliated hepatic foregut cyst in children and adolescents: a systematic review of clinical presentation, diagnosis, management, and outcomes. Pediatric surgery international 70.0 21 Adolescent M-CSF Administration Provides Durable Protection Against Trauma-Induced PTSD-Like Phenotypes in Male Mice Through Microglia-Dependent Mechanisms. Neurochemical research 57.75 22 Multimodal Combination Treatment in a Patient-Centered Approach is Associated with Improved Outcome in Relapsed/Refractory Sarcomas in Children: A Comparative Single-Institution Real-World Analysis. Oncology and therapy 68.18 23 Familial 46,XX Ovotesticular Differences in Sex Development Associated With an NR5A1 p.Arg92Trp Variant. Hormone research in paediatrics 38.5 24 Protective effect of folic acid supplementation on the proportion of micronucleated erythrocytes in Balb-C mice irradiated with computed tomography. International journal of radiation biology 48.5 25 Educating Pediatric Oncology Clinicians on Sexual Health Care for Adolescents and Young Adults With Cancer: Results From a Proof-of-Concept Study. JCO oncology practice 58.0 26 Effects of the GnRH agonist leuprorelin on liver volume in premenopausal women with severe polycystic liver disease. Hepatology communications 63.5 27 Dynamic Proton arc therapy for paediatric parameningeal rhabdomyosarcoma. Journal of applied clinical medical physics 67.54 28 Late-onset hypothalamic-pituitary dysfunction in a childhood cancer survivor treated with cranial irradiation. JCEM case reports 62.8 29 Late cardiopulmonary morbidity in patients with Hodgkin lymphoma: a retrospective nationwide registry study. Annals of hematology 66.6 30 Endoscopic techniques for removal of intraorbital foreign bodies - a clinical series. Acta neurochirurgica 60.9 31 Existing 'In-Between': A Qualitative Exploration of Individual, Interpersonal and Structural Influences on Empowerment Among Young Adults With Chronic Health Conditions. Health expectations : an international journal of public participation in health care and health policy 57.5 32 Transcriptome Analysis Identifies a Myeloid-Like Signature in Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia Patients With Poor Response to CD19 Chimeric Antigen Receptor T Cell Therapy. Cancer medicine 83.78
PATIENT-FRIENDLY SUMMARY

Head-to-Head Comparison of Neuroblastoma Detection by [64Cu]GD2 PET and [123I]MIBG SPECT.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic