← Back to all signals
RESEARCH PAPER ANALYSIS

Clinicopathological, immunohistochemical and therapeutic approaches on survival in patients with epithelioid glioblastoma: Institutional experience in the management of 58 patients.

AI interpretation is pending for this paper.

Open original publication →
PMID39382734
JournalNeurosurgical review
Publication Date2024-10-09
Ingested2026-08-02 12:02 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

Epithelioid glioblastoma (Ep-GBM) is a rare variant of glioblastoma characterized by a high recurrence rate and poor prognosis. Currently, there is no established standard treatment for Ep-GBM. Therefore, we identified 58 Ep-GBM cases to investigate these characteristics and identify the possible prognostic factors of survival. There were 30 male and 28 female patients with a median age of 39 years. Headaches and dizziness were the most common clinical symptom. The tumor is most frequently located in the temporal lobe (36.2%). The positivity rate for BRAF-V600E is 56.9% (33/58), for MGMT is 56.9% (33/58), and for INI-1 is 75% (30/40). Tumor recurrence was observed in 39 patients. The median progression-free survival (PFS) of all patients was 12.7 months, while the median overall survival (OS) was 29.1 months. Additionally, the median survival time after recurrence was 14.3 months. Both univariate and multivariate COX regression analyses revealed that individuals who received more than six cycles of adjuvant oral temozolomide experienced a longer median PFS compared to those who received fewer cycles. Characteristics associated with poorer PFS included tumor dissemination prior to initial surgery. Additionally, both analyses identified tumor dissemination, radiotherapy and adjuvant oral temozolomide as predictors of OS. Notably, for patients with recurrent Ep-GBM, reoperation was shown to significantly increase survival time after recurrence. In conclusion, the standard Stupp regimen is also applicable to patients with Ep-GBM, extending adjuvant oral temozolomide could further improve survival for Ep-GBM patients, reoperation may also prolong survival for recurrent Ep-GBM.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Common Symptom with Rare Entity. Kathmandu University medical journal (KUMJ) 56.4 2 Burden and Projections of Premenopausal and Postmenopausal Breast Cancer Worldwide: A Comprehensive Analysis of GLOBOCAN 2022 Data. The breast journal 40.9 3 Characterizing Pain, Fatigue and Distress Symptom Severity and Classes in Symptomatic Early-Onset Colorectal Cancer Patients. Cancer control : journal of the Moffitt Cancer Center 82.4 4 Bloodstream infection by Fusarium Solani Complex in a paediatric patient affected by acute lymphoblastic leukaemia and P450 cytochrome polymorphism: A case report. Current medical mycology 56.3 5 Improved detection of low-level GNAQ mosaicism in Sturge-Weber syndrome through affected tissue testing, deep sequencing, and HRM-qPCR. Orphanet journal of rare diseases 54.0 6 Validation study of the Korean version of the parent protection scale. Journal of patient-reported outcomes 59.5 7 Knowledge, attitude, and practice regarding testicular cancer and testicular self-examination among medical students in Afghanistan. BMC cancer 63.4 8 Preferences, experiences and needs of parents and adolescents regarding germline sequencing in pediatric oncology. BMC pediatrics 62.5 9 Synchronous B-lymphoblastic leukemia/lymphoma and subcutaneous panniculitis-like T-cell lymphoma in an 11-year-old pediatric patient. BMC pediatrics 56.4 10 Right atrial tumour thrombus in hepatocellular carcinoma: a case report and literature review of anticoagulation dilemmas. BMC gastroenterology 49.1 11 More high-risk patients but stable levels of healthcare-associated infections and antibiotic use: findings from national point prevalence survey conducted in 2017 and 2022 in the Paris region hospitals. Antimicrobial resistance and infection control 64.9 12 Serum decoy receptor 3 (DcR3) concentrations and associations with clinical parameters in Plasmodium vivax and Plasmodium falciparum malaria. Malaria journal 71.4 13 Advanced lung cancer inflammation index predicts in-hospital mortality and refines risk stratification in patients with cirrhosis. BMC gastroenterology 72.0 14 How is the relationship between life style and cardiovascular diseases? A case- control study. BMC public health 70.0 15 Trajectory clustering of longitudinal donor chimerism after pediatric hematopoietic stem cell transplantation for non-malignant disorders. Cytotherapy 62.0 16 The impact of replacing dairy products with plant-based dairy alternatives on iodine and other micronutrients: a modelling study and evaluation of policy options to support population intake. The Lancet. Planetary health 57.5 17 CLINICAL AND CULTURAL PERSPECTIVES ON POLYCYSTIC OVARY SYNDROME IN WOMEN BASED ON SYMPTOM CLUSTERING AND DIAGNOSTIC TRENDS. Georgian medical news 61.4 18 [Thoracic pain in an adolescent with a large intrathoracic mass]. Praxis 57.5 19 Usability Testing to Improve the User Experience of an Electronic Patient-Reported Outcome System for Chimeric Antigen Receptor T-Cell Therapies. JCO clinical cancer informatics 65.1 20 The 2025 KSPNO Guideline for the Diagnosis and Treatment of Medulloblastoma. Brain tumor research and treatment 63.64 21 Diffuse Leptomeningeal Glioneuronal Tumor With Peritoneal Seeding After Ventriculoperitoneal Shunt in an Adult Patient: A Case Report. Brain tumor research and treatment 54.3 22 [Financial Toxicity in Cancer Care-2026 Update]. Gan to kagaku ryoho. Cancer & chemotherapy 75.42 23 Burden of sarcopenia and impact of structured physical programme in children with acute lymphoblastic leukaemia. Chinese clinical oncology 64.6 24 Spinal Cord Compression Syndrome Revealing Thoracic Ewing Sarcoma in a Young Adult: A Case Report. Cureus 45.5 25 Acute Incarceration of Solitary Rectal Ulcer Syndrome as an Anorectal Emergency in an Adolescent Patient: A Case Report With Long-Term Follow-Up and a Review of the Literature. Cureus 53.5 26 Case Report: Neurosurgery, octreotide, cabergoline, radiotherapy, pasireotide and pegvisomant - a multimodal strategy for adolescent acrogigantism. Frontiers in endocrinology 55.84 27 The relationship of homocysteine and its redox forms with renal toxicity after high-dose methotrexate treatment in patients with leukemia or lymphoma. Frontiers in pharmacology 72.38 28 A systematic review on the possible role of microRNA-155 in cancer treatment. Frontiers in pharmacology 75.74 29 Diagnostic delay as a prognostic factor for non-response to treatment and relapse in Mexican pediatric patients with central nervous system tumors. Frontiers in pediatrics 67.98 30 Beyond disease counts: multimorbidity patterns and self-rated health in South African adults-a network analysis of the 2016 demographic and health survey. Frontiers in public health 60.0 31 Deficiency of adenosine deaminase 2 in paediatric patients: a case series from Ireland. Frontiers in pediatrics 61.8 32 Parents' perception of enhanced oncofertility care in childhood cancer patients following routine fertility informing. Frontiers in pediatrics 61.1
PATIENT-FRIENDLY SUMMARY

Clinicopathological, immunohistochemical and therapeutic approaches on survival in patients with epithelioid glioblastoma: Institutional experience in the management of 58 patients.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic