Precision Oncology in Pediatric Cancer Surgery.
This article reviews molecular profiling, targetable mutations, access to targeted therapies, clinical implementation, and surgical implications of precision oncology, with an emphasis on pediatric solid tumors.
Open original publication →What the AI sees
This article reviews molecular profiling, targetable mutations, access to targeted therapies, clinical implementation, and surgical implications of precision oncology, with an emphasis on pediatric solid tumors.
Research significance
The record supports that molecular profiling can identify potentially actionable alterations and inform access to targeted therapies; it is reasonable but not demonstrated here to hypothesize that integrating these findings into pediatric cancer surgery could improve treatment selection, survival, or toxicity outcomes.
Source abstract
Pediatric precision oncology has provided a greater understanding of the wide range of molecular alterations in difficult-to-treat or rare tumors with the aims of increasing survival as well as decreasing toxicity and morbidity from current cytotoxic therapies. In this article, the authors discuss the current state of pediatric precision oncology which has increased access to novel targeted therapies while also providing a framework for clinical implementation in this unique population. The authors evaluate the targetable mutations currently under investigation-with a focus on pediatric solid tumors-and discuss the key surgical implications associated with novel targeted therapies.