← Back to all signals
RESEARCH PAPER ANALYSIS

Validation of Modified Albumin-Bilirubin-Tumor Stage as a Prognostic Model in Early-Stage Hepatocellular Carcinoma Treated With Radiofrequency Ablation.

AI interpretation is pending for this paper.

Open original publication →
PMID42972854
JournalThe Kaohsiung journal of medical sciences
Publication Date2026-11-02
Ingested2026-11-04 10:15 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

Survival after radiofrequency ablation (RFA) for very early- or early-stage hepatocellular carcinoma (HCC) remains heterogeneous because prognosis depends on both tumor burden and hepatic reserve. We retrospectively evaluated treatment-naive patients with Barcelona Clinic Liver Cancer (BCLC) Stages 0 or A HCC treated with RFA as initial therapy from January 2002 to September 2016. Patients with Child-Pugh class A or B and complete ablation were included. Four prespecified total scores, Child-Pugh-tumor (CP-T), albumin-bilirubin-tumor (ALBI-T), modified ALBI-tumor (mALBI-T), and platelet-ALBI-tumor (pALBI-T) were compared using the Akaike information criterion (AIC), Harrell concordance index (C-index), time-dependent area under the receiver operating characteristic curve, calibration, and subgroup analyses. Of 1238 patients screened, 950 were included; 831 (87.5%) were Child-Pugh class A. During a median follow-up of 5.44 years, 417 deaths occurred; 5- and 10-year overall survival rates were 58.0% and 35.8%, respectively. The American Joint Committee on Cancer eighth-edition T stage illustrated the best tumor-stage performance and was used in the total scores, while mALBI-T had the lowest AIC (5052.2) and highest Harrell C-index (0.628; 95% confidence interval, 0.601-0.655). Paired bootstrap differences versus CP-T, ALBI-T, and pALBI-T were statistically significant, but modest, while mALBI-T performed best at 5 years and in Child-Pugh class A patients, whereas all models showed limited discrimination in Child-Pugh class B patients. Apparent calibration was generally close, and mALBI-T also had the best fit for recurrence-free survival. mALBI-T provides a simple prognostic model for long-term survival stratification after complete ablation in early-stage hepatocellular carcinoma, especially in Child-Pugh class A patients.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Fear of Recurrence and Medication Adherence in Pediatric Leukaemia Survivors in Low-Resource Settings. Juntendo medical journal 70.8 2 Histopathologically Compatible Neurocysticercosis Mimicking an Intracranial Tumor in a Child. Iranian journal of parasitology 60.8 3 Direct medical costs of chronic diseases in Jordan: a systematic review. Health economics review 71.5 4 Panniculitis masquerading as generalised lymphadenopathy in a neonate: a diagnostic dilemma - a case report and a mini review. BMC pediatrics 49.0 5 The therapeutic landscape of cannabidiol: a systematic review of molecular mechanisms, clinical efficacy in oncology and neurology, and regulatory changes. Journal of cannabis research 81.79 6 Integrating Pediatric Dentistry Into Multidisciplinary Palliative Care for Pediatric Oral Cancer Patients: A Scoping Review. Sage open pediatrics 60.8 7 [Clinical characteristics in different age subgroups of non-pregnant young patients with papillary thyroid carcinoma]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery 63.9 8 Unusual presentation of pediatric lichen planus with cutaneous, oral, and nail involvement: a case report. Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD 49.9 9 Sex differences in gastrointestinal cancers incidence and mortality among adolescents and young adults in China: an age-period-birth cohort study. Journal of translational internal medicine 57.5 10 Diffuse brainstem gliomas across the pediatric, adolescent, and adult age spectrum: Clinical and radiological features, molecular profile, and determinants of survival in a multicenter retrospective cohort of 42 patients. Surgical neurology international 69.02 11 Co-targeting CDK2 and CDK9 inhibits MYC oncogenic programs and has anti-tumor effects in CIC-rearranged sarcoma. Communications medicine 54.9 12 Cervicothoracic intramedullary teratoma in a 6-year-old child: A case report. Surgical neurology international 45.5 13 Occipital interhemispheric transtentorial approach for microsurgical resection of a posterior fossa medulloblastoma: 2-dimensional operative video. Surgical neurology international 59.9 14 Calvarial erosion secondary to epithelioid glioblastoma: A molecularly characterized case report. Surgical neurology international 55.0 15 Longitudinal changes in bone mineral density, bone turnover markers, and body composition in children and adolescents treated for acute lymphoblastic leukemia. Frontiers in endocrinology 61.9 16 Case Report: Successful treatment of drug-resistant epilepsy with unilateral deep brain stimulation of the anterior nucleus of the thalamus. Frontiers in neuroscience 58.0 17 Surgical resection combined with TACE for primary clear cell carcinoma of the liver: a case report and literature review. Frontiers in surgery 49.9 18 Hypomorphic biallelic LIFR variants define a multisystem disorder with survival beyond infancy and hyperinflammatory vulnerability. Frontiers in immunology 61.72 19 Cancer Stem Cells in Drug Delivery Strategies: Current Advances and Future Directions. Current drug delivery 62.16 20 Calcified choroid plexus papilloma of the temporal horn presenting with seizures in an adult without hydrocephalus: An illustrative case. Surgical neurology international 59.9 21 TRIM65-BTG3-HIF-1α axis drives osteosarcoma progression via M2 macrophage polarization and angiogenesis. Journal of translational internal medicine 53.4 22 Pediatric Leptomeningeal Glial Tumors: A Retrospective Case Series and Review of the Literature. Turkish archives of pediatrics 63.3 23 Management of Obesity in Special Populations and Limited-Resource Settings: An Egyptian Medical Position Statement. Diabetes, metabolic syndrome and obesity : targets and therapy 61.9 24 Voxelwise white-matter compositional connectivity mapping from diffusion MRI via reliability-aware hierarchical inference. Medical image analysis 56.0 25 The visible and invisible scars of childhood cancer: A qualitative study of body image and identity in survivorship. British journal of health psychology 59.6 26 Cytogenetic Landscape of Complex Karyotypes Across Hematological Malignancies: Common and Disease-Specific Patterns in a Large Single-Center Cohort. Genes, chromosomes & cancer 63.7 27 Dynamics of the Prevalence of Non-communicable Diseases in the Urban Double Cotonou - Abomey-Calavi (South of Benin). The Nigerian postgraduate medical journal 38.5 28 A 17-cm ileocecal inflammatory myofibroblastic tumor with severe inflammatory syndrome in a child: a case report. Journal of surgical case reports 45.5 29 Giant Lipoma of the Thoracic Wall in a Two-Year-Old Girl: Imaging Features Supporting a Benign Diagnosis. Cureus 57.5 30 Retrospective Study of Implementation and Outcomes of a Non-Cryopreserved Autologous Hematopoietic Stem Cell Transplantation Program for Patients With Hematologic Malignancy in a Resource-Limited Center in Chile. Annals of transplantation 69.1 31 Children of advanced cancer patients need better support: A case report. Palliative & supportive care 49.5 32 An integrated MRI-pathology model for predicting response to TACE combined with targeted therapy and immunotherapy in hepatocellular carcinoma. European radiology 84.02
PATIENT-FRIENDLY SUMMARY

Validation of Modified Albumin-Bilirubin-Tumor Stage as a Prognostic Model in Early-Stage Hepatocellular Carcinoma Treated With Radiofrequency Ablation.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic