A grade PMID 42321916
View analysis →Finding therapies hidden in 37,335 pediatric cancer papers.
Neurocompute scores pediatric oncology literature, surfaces overlooked therapeutic signals, and turns fragmented childhood cancer research into a living discovery terminal.
Ranked Discovery Journal Articles
A grade PMID 42372741
View analysis →A grade PMID 42216567
View analysis →A grade PMID 41916649
View analysis →A grade PMID 42382416
View analysis →A grade PMID 42150584
View analysis →A grade PMID 41756844
View analysis →A grade PMID 42362103
View analysis →A grade PMID 42101908
View analysis →A grade PMID 42248607
View analysis →A grade PMID 41667193
View analysis →A grade PMID 42260111
View analysis →Database feed
All ranked pediatric cancer papers
In 130 patients with endometrial carcinoma, a nomogram combining age, Ki-67 index, and preoperative lymphocyte-to-monocyte ratio predicted postoperative high-risk classification with an AUC of 0.904 in the training set and 0.846 in a 23-patient validation set.
The evidence supports this nomogram as a potential preoperative risk-stratification tool; it may, by inference, help select patients for intensified evaluation or treatment planning, but the record does not show that its use changes therapy, survival, toxicity, or other clinical outcomes.
This case series reports seven children with pulmonary tuberculosis presenting as mass-like radiographic or CT opacities that mimicked chest neoplasms and were subsequently confirmed as tuberculosis.
The reported evidence supports including tuberculosis in the differential diagnosis of pediatric pulmonary masses in endemic or resource-limited settings; it is reasonable but unproven to infer that earlier microbiologic and clinicoradiologic evaluation could prevent diagnostic delay, inappropriate cancer-directed procedures, and delayed antituberculous treatment.
This single-institution retrospective series describes the clinicopathological features, risk categories, and use of chemotherapy, surgery, and radiotherapy in 12 children with histologically confirmed rhabdomyosarcoma.
The record supports multidisciplinary, risk-stratified management as observed clinical practice; it does not demonstrate that any particular treatment strategy improves outcomes, although the cohort could generate hypotheses about care patterns in this population.
In a retrospective cohort of 32 pediatric patients with papillary thyroid carcinoma, extrathyroidal extension was independently associated with cervical lymph node metastasis after adjustment for T stage and lymphatic invasion.
The evidence supports extrathyroidal extension as a potential clinicopathologic risk marker; it may help select patients for closer postoperative surveillance, but improved outcomes, treatment selection, and the optimal surveillance strategy were not tested.
This case report describes a 22-month-old girl with DiGeorge syndrome and juvenile idiopathic arthritis who achieved remission after six months of etanercept following ineffective naproxen and methotrexate, alongside a review of 51 reported cases.
The record provides low-level human evidence that TNF inhibition may control refractory JIA in some children with DiGeorge syndrome; it is only an inference that this represents a broadly effective or acceptably safe strategy because the primary evidence is a single case and the review supplies limited response and safety detail.
This practical '10 Tips' paper presents a multidisciplinary, patient-centred framework for selecting cancer patients for kidney biopsy, managing procedural risk, and interpreting findings, including in high-risk and end-of-life settings.
The paper states that identifying renal lesions by biopsy can guide oncologic therapy and help prevent further renal decline; it is reasonable to infer that better biopsy selection and interpretation could reduce inappropriate treatment changes or nephrotoxicity, but the supplied record provides no comparative or outcome evidence supporting this hypothesis.
This multicenter cross-sectional study surveyed 813 caregivers across 14 Polish pediatric oncology and hematology wards, finding generally favorable hospital ratings but substantially lower scores for preventing mistakes and helping families report concerns.
The evidence identifies caregiver communication, comfort, safety, and concern-reporting as potential quality-improvement targets; it is reasonable—but not demonstrated by this study—to hypothesize that PPEQ-guided interventions could improve care experiences, safety, or treatment delivery.
This case report describes a pregnant 25-year-old with classical Hodgkin lymphoma who received two antenatal ABVD cycles, delivered a healthy neonate at 37 weeks, and achieved complete remission after completing chemotherapy postpartum.
The reported case provides evidence that ABVD administration during later pregnancy can coincide with favorable short-term maternal and neonatal outcomes under multidisciplinary monitoring; it only supports the inference—not proof—that this approach may be feasible for selected pregnant patients with Hodgkin lymphoma.
This case report describes a 15-month-old child receiving chemotherapy for optic glioma who developed large non-traumatic bilateral subdural hematomas and improved clinically and radiologically after urgent surgical evacuation and drain placement.
The reported case supports prompt neurosurgical evacuation for symptomatic subdural hematomas with mass effect; it only suggests, without establishing, that serial head-circumference assessment and timely neuroimaging might facilitate earlier detection in selected young children undergoing CNS-tumor treatment.
This case report describes a 2-month-old infant with a malignant intra-abdominal mixed germ cell tumour initially suspected to be hepatoblastoma who remained disease free at 3 years after resection and adjuvant bleomycin, carboplatin, and etoposide chemotherapy.
The reported outcome provides limited evidence that surgery followed by platinum-based combination chemotherapy can achieve durable disease control in this rare presentation; it is only an inference—not established by this single case—that this approach is broadly effective or optimal for neonatal intra-abdominal mixed germ cell tumours.
In neonatal MHV68-infected mice, genetic background, viral inoculum, and sex were associated with differences in systemic latent infection, germinal-center responses, and splenomegaly, with latent virus localized to splenic germinal-center B cells in susceptible animals.
The evidence shows that host genetic background and exposure dose modify neonatal gammaherpesvirus latency and B-cell responses in mice; it can only be inferred—not established—that identifying the responsible host pathways might reveal targets for preventing or limiting chronic infection and subsequent virus-associated malignancy risk.
This case report describes an 11-year-old girl with triquetral osteoid osteoma initially suspected to have septic arthritis on MRI, subsequently identified by high-resolution CT and confirmed histologically after surgical excision relieved her symptoms.
The reported evidence supports CT-guided recognition followed by surgical excision in this individual case; it suggests—but does not establish—that earlier CT imaging in children with persistent nocturnal, salicylate-responsive wrist pain and disproportionate MRI edema could reduce diagnostic delay and unnecessary infection-directed care.