← Back to all signals
RESEARCH PAPER ANALYSIS

Utility of carboplatin therapeutic drug monitoring for the treatment of neonate and infant retinoblastoma patients in the United Kingdom.

AI interpretation is pending for this paper.

Open original publication →
PMID38871807
JournalBritish journal of cancer
Publication Date2024-06-13
Ingested2026-08-02 12:02 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

BACKGROUND: Retinoblastoma is the most common intra-ocular malignancy in children and frequently presents in very young patients who commonly require intravenous carboplatin. Delivering this is challenging due to a lack of uniform dosing recommendations, rapid changes in physiological function and the risk of side-effects. METHODS: We conducted a retrospective review of neonates and infants in the UK with retinoblastoma, who have undergone carboplatin therapeutic drug monitoring (TDM). We report on the pharmacokinetic, treatment efficacy and toxicity data. RESULTS: In total, 29 patients (median age 5 weeks at treatment onset) underwent a total of 74 TDM guided cycles of chemotherapy, involving real time sampling and dose adjustment. An additional 13 patients underwent TDM sampling to modify doses between cycles. Without the adoption of TDM guided dosing, carboplatin exposures would have been ≥20% outside the target AUC in 38/78 (49%) of treatment cycles. Excellent responses and a reassuringly low incidence of toxicities were observed following dose adjustment, despite the young patient age and the implementation of dose increases in the majority of cases. CONCLUSIONS: Real time TDM is safe, effective and deliverable for neonates and infants receiving carboplatin for retinoblastoma and should be considered standard of care up to the age of 6 months.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 [Allogeneic hematopoietic stem cell transplantation for 510 patients with active relapsed/refractory acute myeloid leukemia: a real-world study]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 70.74 2 [Clinical characteristics and prognosis of acute myeloid leukemia patients with RUNX1 single-site and multiple-site gene mutations]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 73.4 3 Lymphoma presenting as a genitourinary lesion in children: A case series highlighting diagnostic challenges and the risk of unnecessary organ resection. Journal of pediatric urology 73.8 4 Posterior Reversible Encephalopathy Syndrome (PRES) in an Anuric Patient With a WT1 Mutation and Chronic Renal Graft Failure: A Case Report. Cureus 52.7 5 Gestational hypercalcemia: a narrative review of literature. Frontiers in medicine 60.9 6 [Surgical designs and clinical effects of pedicled transfer of extended lower trapezius musculocutaneous flap in repairing massive wounds in the shoulder and back]. Zhonghua shao shang yu chuang mian xiu fu za zhi 57.7 7 Identification of the Characteristics and Prognostic Impact of t(3;5)(q25;q35)/NPM1::MLF1 Fusion Genes and NPM1 Mutations in Acute Myeloid Leukemia Patients. Clinical lymphoma, myeloma & leukemia 63.9 8 Oral bacteriome in pediatric patients with malignancies prior to chemotherapy: a pilot study using full-length 16S rRNA sequencing. Frontiers in cellular and infection microbiology 65.44 9 hNET-targeted [18F]MFBG PET as baseline functional imaging in newly diagnosed neuroblastoma. Theranostics 64.3 10 [Clinical analysis of 26 littoral cell angioma of the spleen cases]. Zhonghua yi xue za zhi 61.6 11 An Art Therapy Workbook for Pediatric Patients with Cancer Receiving Palliative Care: Program Design and Effects. Journal of hospice and palliative care 62.24 12 Population-Level Trends in Gastric Cancer Mortality and Incidence After Expansion of Japanese National Health Insurance Coverage for Helicobacter pylori Eradication: A Descriptive Time-Trend Study. Helicobacter 64.3 13 Blinatumomab Care Delivery for Pediatric B-Cell Acute Lymphoblastic Leukemia. JAMA network open 78.6 14 From Innocence to Endurance: A Patient's Perspective on Lifelong Transplant Care. Journal of cardiac failure 54.0 15 Psychosocial interventions for reducing pain and pain-related distress in infants, children, and adolescents undergoing cancer treatment: a systematic review and meta-analysis of randomized control trials. Pain 70.94 16 Current status and influencing factors of fertility preservation decisional conflict among female cancer patients of childbearing age: A scoping review. European journal of oncology nursing : the official journal of European Oncology Nursing Society 74.4 17 Identification of the Genomic Etiology of Unexplained Congenital Problems in Pediatric Patients: First Reported Case With Coffin-Siris Syndrome and Sialuria From India. Clinical case reports 47.5 18 Integrated expression profiling of BCR-ABL and computational identification of ABL1 inhibitors in pediatric acute lymphoblastic leukemia. In silico pharmacology 68.46 19 Deep Learning Pipeline for Automatic Segmentation, Classification, and Molecular Subtyping of Three Pediatric Posterior Fossa Tumors Using T2-Weighted MRI. Journal of magnetic resonance imaging : JMRI 66.9 20 Reduced-dose Radiotherapy without Chemotherapy for Intracranial Germinomas: Results from an Asian Multicenter Study. Neuro-oncology 90.06 21 Pulmonary function in young childhood cancer survivors: results from a prospective multicentre cohort. ERJ open research 67.5 22 Differential in vivo tyrosine kinase inhibitor sensitivities of pediatric ABL-class Ph-like B-acute lymphoblastic leukemia. HemaSphere 49.66 23 Cryptic and Overt Acute Kidney Injury Share Biomarker Characteristics in Pediatric Acute Respiratory Distress Syndrome. Critical care explorations 57.35 24 [Proliferative nodule within a giant congenital melanocytic nevus: report of a case]. Zhonghua bing li xue za zhi = Chinese journal of pathology 28.5 25 Fertility preservation in women with central nervous system tumors. Expert review of anticancer therapy 79.2 26 Molecular profiling of pediatric medulloblastoma in Kazakhstan: Genomic alterations, subgroup distribution, and survival. Brain pathology (Zurich, Switzerland) 61.12 27 Association of a Child's Rare Disease Neurofibromatosis 1 with Parental Income and Employment Trajectories Following the Child's Birth. Genetics in medicine : official journal of the American College of Medical Genetics 61.0 28 Clinical Outcomes of Younger Adults With Philadelphia-Negative Acute Lymphoblastic Leukemia, Treated With A Pediatric-Like Regimen Based on the GIMEMA LAL1308 Protocol. A Campus ALL Study. European journal of haematology 84.6 29 Adnexal torsion due to teratoma in a young adolescent. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 56.0 30 Methylation profiling in CNS tumor diagnostics: a single-centre real-world experience from Central Europe. Virchows Archiv : an international journal of pathology 57.5 31 Pancreatic stent and transpapillary pseudocyst drainage via endoscopic retrograde cholangiopancreatography for children with blunt pancreatic duct injury. European journal of trauma and emergency surgery : official publication of the European Trauma Society 58.4 32 Geospatial assessment of groundwater quality, heavy metal contamination and human health risks in the rapidly industrializing and agriculturally dominated Shivalik Himalaya, India. Environmental geochemistry and health 59.9
PATIENT-FRIENDLY SUMMARY

Utility of carboplatin therapeutic drug monitoring for the treatment of neonate and infant retinoblastoma patients in the United Kingdom.

For education only—not personal medical advice.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic