← Back to all signals
RESEARCH PAPER ANALYSIS

Sperm Quality in 1252 Adolescents and Young Adults (AYAs) Undergoing Fertility Preservation Due to Cancer or Nonmalignant Diseases.

AI interpretation is pending for this paper.

Open original publication →
PMID39069896
JournalJournal of adolescent and young adult oncology
Publication Date2024-07-29
Ingested2026-08-02 12:03 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

Purpose: To investigate the quality of emergency-collected semen samples aimed at sperm cryopreservation provided by adolescents and young adults (AYAs) presenting with cancer or nonmalignant diseases. Methods: This is a prospective cohort study of postpubertal males referred for sperm cryopreservation who provided at least one semen sample for fertility preservation at the Reproductive Medicine Clinic of Karolinska University Hospital, Stockholm, Sweden, between January 2009 and January 2020. Sperm quality was assessed by total sperm count, concentration, and motility. Sperm quality by disease groups was compared with the reference population data of fertile men defined by the World Health Organization (WHO). Results: Among the 1252 patients who provided samples for cryopreservation, 1063 had cancer and 189 had nonmalignant diseases. The most common malignant indications included testicular cancers (n = 501) and Hodgkin lymphoma (n = 102). Among those with nonmalignant disease, 35% (n = 66) had testicular disease. Sperm quality was significantly lower in all groups of patients with cancer compared with the reference population. In total, azoospermia was found in 8% of the patients with cancer, in 9% of those with nonmalignant testicular disease, and in 3% of the remaining men with nonmalignant disease. Conclusion: Sperm quality in adult patients with cancer was significantly impaired compared with the WHO reference population standards for fertile men. For adolescent patients, standard reference values are lacking. AYAs wishing to preserve fertility should receive individualized counseling regarding sperm quality at the time of cryopreservation, and in selected cases, banking of additional samples should be recommended depending on the sperm quality parameters.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Fear of Recurrence and Medication Adherence in Pediatric Leukaemia Survivors in Low-Resource Settings. Juntendo medical journal 70.8 2 Histopathologically Compatible Neurocysticercosis Mimicking an Intracranial Tumor in a Child. Iranian journal of parasitology 60.8 3 Direct medical costs of chronic diseases in Jordan: a systematic review. Health economics review 71.5 4 Panniculitis masquerading as generalised lymphadenopathy in a neonate: a diagnostic dilemma - a case report and a mini review. BMC pediatrics 49.0 5 The therapeutic landscape of cannabidiol: a systematic review of molecular mechanisms, clinical efficacy in oncology and neurology, and regulatory changes. Journal of cannabis research 81.79 6 Integrating Pediatric Dentistry Into Multidisciplinary Palliative Care for Pediatric Oral Cancer Patients: A Scoping Review. Sage open pediatrics 60.8 7 [Clinical characteristics in different age subgroups of non-pregnant young patients with papillary thyroid carcinoma]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery 63.9 8 Unusual presentation of pediatric lichen planus with cutaneous, oral, and nail involvement: a case report. Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD 49.9 9 Sex differences in gastrointestinal cancers incidence and mortality among adolescents and young adults in China: an age-period-birth cohort study. Journal of translational internal medicine 57.5 10 Diffuse brainstem gliomas across the pediatric, adolescent, and adult age spectrum: Clinical and radiological features, molecular profile, and determinants of survival in a multicenter retrospective cohort of 42 patients. Surgical neurology international 69.02 11 Co-targeting CDK2 and CDK9 inhibits MYC oncogenic programs and has anti-tumor effects in CIC-rearranged sarcoma. Communications medicine 54.9 12 Cervicothoracic intramedullary teratoma in a 6-year-old child: A case report. Surgical neurology international 45.5 13 Occipital interhemispheric transtentorial approach for microsurgical resection of a posterior fossa medulloblastoma: 2-dimensional operative video. Surgical neurology international 59.9 14 Calvarial erosion secondary to epithelioid glioblastoma: A molecularly characterized case report. Surgical neurology international 55.0 15 Longitudinal changes in bone mineral density, bone turnover markers, and body composition in children and adolescents treated for acute lymphoblastic leukemia. Frontiers in endocrinology 61.9 16 Case Report: Successful treatment of drug-resistant epilepsy with unilateral deep brain stimulation of the anterior nucleus of the thalamus. Frontiers in neuroscience 58.0 17 Surgical resection combined with TACE for primary clear cell carcinoma of the liver: a case report and literature review. Frontiers in surgery 49.9 18 Hypomorphic biallelic LIFR variants define a multisystem disorder with survival beyond infancy and hyperinflammatory vulnerability. Frontiers in immunology 61.72 19 Cancer Stem Cells in Drug Delivery Strategies: Current Advances and Future Directions. Current drug delivery 62.16 20 Calcified choroid plexus papilloma of the temporal horn presenting with seizures in an adult without hydrocephalus: An illustrative case. Surgical neurology international 59.9 21 TRIM65-BTG3-HIF-1α axis drives osteosarcoma progression via M2 macrophage polarization and angiogenesis. Journal of translational internal medicine 53.4 22 Pediatric Leptomeningeal Glial Tumors: A Retrospective Case Series and Review of the Literature. Turkish archives of pediatrics 63.3 23 Management of Obesity in Special Populations and Limited-Resource Settings: An Egyptian Medical Position Statement. Diabetes, metabolic syndrome and obesity : targets and therapy 61.9 24 Voxelwise white-matter compositional connectivity mapping from diffusion MRI via reliability-aware hierarchical inference. Medical image analysis 56.0 25 The visible and invisible scars of childhood cancer: A qualitative study of body image and identity in survivorship. British journal of health psychology 59.6 26 Cytogenetic Landscape of Complex Karyotypes Across Hematological Malignancies: Common and Disease-Specific Patterns in a Large Single-Center Cohort. Genes, chromosomes & cancer 63.7 27 Dynamics of the Prevalence of Non-communicable Diseases in the Urban Double Cotonou - Abomey-Calavi (South of Benin). The Nigerian postgraduate medical journal 38.5 28 Validation of Modified Albumin-Bilirubin-Tumor Stage as a Prognostic Model in Early-Stage Hepatocellular Carcinoma Treated With Radiofrequency Ablation. The Kaohsiung journal of medical sciences 70.5 29 A 17-cm ileocecal inflammatory myofibroblastic tumor with severe inflammatory syndrome in a child: a case report. Journal of surgical case reports 45.5 30 Giant Lipoma of the Thoracic Wall in a Two-Year-Old Girl: Imaging Features Supporting a Benign Diagnosis. Cureus 57.5 31 Retrospective Study of Implementation and Outcomes of a Non-Cryopreserved Autologous Hematopoietic Stem Cell Transplantation Program for Patients With Hematologic Malignancy in a Resource-Limited Center in Chile. Annals of transplantation 69.1 32 Children of advanced cancer patients need better support: A case report. Palliative & supportive care 49.5
PATIENT-FRIENDLY SUMMARY

Sperm Quality in 1252 Adolescents and Young Adults (AYAs) Undergoing Fertility Preservation Due to Cancer or Nonmalignant Diseases.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic