← Back to all signals
RESEARCH PAPER ANALYSIS

SUV normalisation and reference tissue selection for [1⁸F]mFBG PET-CT in paediatric and adult patients.

AI interpretation is pending for this paper.

Open original publication →
PMID40172693
JournalEuropean journal of nuclear medicine and molecular imaging
Publication Date2025-04-02
Ingested2026-08-02 12:04 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

PURPOSE: Meta-[1⁸F]fluorobenzylguanidine ([1⁸F]mFBG) PET-CT is a novel imaging modality for norepinephrine transporter-expressing tumours, such as neuroblastoma and phaeochromocytoma, enabling quantitative assessment and improved diagnostic accuracy compared to meta-[123I]iodobenzylguanidine ([123I]mIBG) scintigraphy. This study aims to: 1) Identify the optimal standardised uptake value (SUV) normalisation method: body weight (BW) or lean body mass (LBM); 2) Determine the most stable reference tissue with SUV uptake below pathological levels. METHODS: We analysed 63 [1⁸F]mFBG PET-CTs from 35 patients (20 paediatric neuroblastoma, 15 adult phaeochromocytoma). SUVmean was measured in the liver, blood pool, bone marrow, and muscle, normalised using BW (SUVBW), LBM via James (SUVLBMJames), and LBM via Janmahasatian (SUVLBMJanma). Variability of SUVs and their correlation with weight were assessed. RESULTS: LBM-based normalisation reduced SUV variability compared to BW-based normalisation. Bone marrow demonstrated the lowest variability and least weight dependency (r2 0.45 for SUVBW versus 0.31 for SUVLBMJanma). The liver had the highest SUVs, increasing the risk of false negatives if used as reference tissue, while the blood pool had the lowest SUVs, raising the risk of false positives. Muscle showed relatively stable SUVs with increasing weight but higher variability than bone marrow. CONCLUSION: LBM-based SUV normalisation reduces weight dependency for [1⁸F]mFBG PET-CT. Bone marrow is the most reliable reference tissue due to its low variability and balanced SUVs, while muscle may serve as an alternative if diffuse bone marrow uptake is present. These findings support standardising LBM-adjusted SUV methods and using bone marrow as the primary reference tissue to enhance diagnostic accuracy. CLINICAL TRIAL REGISTRATION: EudraCT Number: 2019-003713-33; EU Clinical Trials Number: 2024-513622-35-00.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 A Rare t(1;11)(q42;q23) Rearrangement with Trisomy 8 and Trisomy 21 in a Pediatric Acute Myeloid Leukemia Patient with Aberrant CD7 Expression and Jacob Syndrome: Diagnostic Value of Conventional Cytogenetics and Fluorescence in Situ Hybridization in a Rapidly Fatal Case. Journal of the Association of Genetic Technologists 56.0 2 A Highly Abnormal Clone in a Pediatric Patient with B-Lymphoblastic Leukemia. Journal of the Association of Genetic Technologists 47.5 3 Maternal polycystic ovary syndrome and the risk of neurodevelopmental disorders in preterm neonates. Pediatric endocrinology, diabetes, and metabolism 65.5 4 [Clinical analysis of 3 cases of childhood primary pure erythroid leukemia and literature review]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 64.4 5 [A retrospective analysis of clinicopathological features and efficacy in 51 patients with high-grade B-cell lymphoma with 11q abnormalities]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 72.1 6 [RET fusion-driven papillary thyroid cancer in children and adolescents: clinical characteristics, molecular mechanisms, and therapeutic advances]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 52.09 7 The diagnostic value of cyclin d1, EGFR, P53 and Ki-67 in epithelial dysplasi of the gallbladder. JPMA. The Journal of the Pakistan Medical Association 60.0 8 Increased brain cancer risk from constant mobile phone use in children. JPMA. The Journal of the Pakistan Medical Association 47.5 9 Pediatric Scurvy Presenting With Vertebral Insufficiency Fractures Mimicking Chronic Recurrent Multifocal Osteomyelitis in a Child With Autism Spectrum Disorder. Cureus 58.4 10 Behind the Curtain: A Pediatric Dermoid Tumor Masquerading as Craniopharyngioma. Cureus 56.0 11 Case Report: novel mutations in SMARCA4 cause Coffin-Siris syndrome type 4 with autism spectrum disorder without visual impairment in one patient. Frontiers in genetics 71.5 12 [Clinicopathological analysis of 18 cases of ovarian juvenile granulosa cell tumor]. Zhonghua fu chan ke za zhi 65.3 13 Efficacy and Safety of CAR-T Cell Therapy in Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia With Central Nervous System Involvement. Cancer medicine 76.66 14 Endothelial and Vascular Toxicity Signals Associated With Doxorubicin: A Pharmacovigilance Analysis of the FDA Adverse Event Reporting System (FAERS) Database. Pharmacoepidemiology and drug safety 67.34 15 Pediatric patients with cancer exhibit increased neutrophil extracellular traps and reduced active deoxyribonuclease I: diagnostic, prognostic, and therapeutic opportunities. Clinical and experimental pediatrics 73.44 16 Hepatocellular Carcinoma at a Center of Clinical Excellence in Colombia: A Real-World Cohort Study of Clinical Characteristics, Treatment Trajectories, and Survival. Journal of hepatocellular carcinoma 71.86 17 [Hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion in a childhood cancer survivor ‒ The role of oral urea in treatment]. Nutricion hospitalaria 59.54 18 NRF2 activation is required for chemotherapy resistance acquisition in medulloblastoma via metabolic and redox adaptation. Redox biology 62.94 19 Oncofertility care evaluation of 599 children and adolescents with cancer and a high risk of treatment-induced gonadal damage: a national paediatric oncology cohort study. Human reproduction (Oxford, England) 78.64 20 Epithelioid hemangioma from inferior turbinate in a pediatric patient: a case report. Journal of surgical case reports 45.5 21 Occupational Therapy Interventions for Pediatric Cancer: A Systematic Review and Meta-Analysis. Physical & occupational therapy in pediatrics 82.84 22 Ovarian Teratoma After Treatment for Coexisting Anti-NMDA Receptor and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Encephalitis. Journal of child neurology 63.8 23 Insight into the Development of Desirable Dosage Forms and Bioenabling Strategies to Improve the Food Effect of Anticancer Drugs for the Pediatric Population. Molecular pharmaceutics 61.76 24 Evaluation of a Rapid Immunoassay for Molecular Subphenotype Classification in Pediatric Acute Cardiorespiratory Failure. Critical care medicine 69.6 25 "A dicey situation:" asymptomatic hypertensive urgency caused by DICER1 mutation-derived cystic nephroma in a 12-month-old. Pediatric nephrology (Berlin, Germany) 56.4 26 Distinct molecular profiles of indeterminate and malignant thyroid nodules in patients under 21 years of age. Endocrine-related cancer 64.5 27 Pediatric Myocarditis: Contemporary Insights Into Viral and Immune-Mediated Pathobiology, Precision Diagnostics, Advanced Multimodality Imaging, Risk Stratification, and Evolving Therapeutic Strategies. Cardiology in review 75.0 28 Clinical characteristics, prognosis, and achievement of transplant in adolescents and adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in Argentina. Hematology, transfusion and cell therapy 71.8 29 "Like a Clinical Nurse Consultant in Your Pocket"-Parents' and Health Care Providers' Perceptions of a Co-Designed Smartphone App Following Treatment for Pediatric Cancer: Mixed Methods Evaluation Study. JMIR cancer 61.94 30 Management of Clostridioides difficile infections in patients with hematological malignancies - a survey by European Conference on Infections in Leukemia (ECIL) and Infectious Diseases Working Party (IDWP) of The European Society for Blood and Marrow Transplantation (EBMT). International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 63.6 31 Polycyclic aromatic hydrocarbon (PAH) levels in indoor air and their associated health risks for children across Europe. Environmental research 57.5 32 Utility and applications of high-field 1.5 T intraoperative magnetic resonance imaging in paediatric neurosurgery: a review of 5 years' experience. Neurocirugia 59.5
PATIENT-FRIENDLY SUMMARY

SUV normalisation and reference tissue selection for [1⁸F]mFBG PET-CT in paediatric and adult patients.

For education only—not personal medical advice.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic