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RESEARCH PAPER ANALYSIS

Association between medical comorbidities at diagnosis and paediatric acute lymphoblastic leukaemia and lymphoblastic lymphoma outcomes: protocol for a systematic review.

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PMID40480668
JournalBMJ open
Publication Date2025-06-06
Ingested2026-08-02 12:04 AM
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ABSTRACT

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INTRODUCTION: Medical comorbidity at diagnosis is associated with treatment outcome in cancer. The aim of this project is to synthesise the evidence on the association between medical comorbidities and paediatric acute lymphoblastic leukaemia and lymphoblastic lymphoma outcomes. METHODS AND ANALYSIS: A systematic review of the literature will be conducted by developing a search strategy that will combine medical subject headings and natural language key words related to acute lymphoblastic leukaemia or lymphoma, medical comorbidities and treatment-related outcomes. We will search MEDLINE and EMBASE to identify studies in human subjects and written in English from the inception of each database to 30 September 2022. Two authors will independently screen the titles and abstracts of retrieved studies based on the inclusion and exclusion criteria to identify potentially eligible studies. Full-text articles of eligible studies and final included articles will be retrieved and reviewed in a similar manner by two independent reviewers. Data extraction from included articles will be conducted independently by two authors using a standardised data extraction form. Risk of bias in the included studies will be assessed using existing relevant tools. A narrative and tabular summary of the data, including outcomes, will be provided if the data do not warrant a meta-analysis. If a meta-analysis is feasible, we will pool all the effect estimates. Heterogeneity among study effect sizes will be tested with Cochran's Q test and quantified by the I2 statistic. ETHICS AND DISSEMINATION: This study will not include the collection of original data, but it will be a summary of aggregate existing data. Thus, ethics approval is not applicable. The findings of the study will be disseminated through peer-reviewed publications. PROSPERO REGISTRATION NUMBER: CRD42022366669.

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Frontiers in surgery 49.9 18 Hypomorphic biallelic LIFR variants define a multisystem disorder with survival beyond infancy and hyperinflammatory vulnerability. Frontiers in immunology 61.72 19 Cancer Stem Cells in Drug Delivery Strategies: Current Advances and Future Directions. Current drug delivery 62.16 20 Calcified choroid plexus papilloma of the temporal horn presenting with seizures in an adult without hydrocephalus: An illustrative case. Surgical neurology international 59.9 21 TRIM65-BTG3-HIF-1α axis drives osteosarcoma progression via M2 macrophage polarization and angiogenesis. Journal of translational internal medicine 53.4 22 Pediatric Leptomeningeal Glial Tumors: A Retrospective Case Series and Review of the Literature. Turkish archives of pediatrics 63.3 23 Management of Obesity in Special Populations and Limited-Resource Settings: An Egyptian Medical Position Statement. Diabetes, metabolic syndrome and obesity : targets and therapy 61.9 24 Voxelwise white-matter compositional connectivity mapping from diffusion MRI via reliability-aware hierarchical inference. Medical image analysis 56.0 25 The visible and invisible scars of childhood cancer: A qualitative study of body image and identity in survivorship. British journal of health psychology 59.6 26 Cytogenetic Landscape of Complex Karyotypes Across Hematological Malignancies: Common and Disease-Specific Patterns in a Large Single-Center Cohort. Genes, chromosomes & cancer 63.7 27 Dynamics of the Prevalence of Non-communicable Diseases in the Urban Double Cotonou - Abomey-Calavi (South of Benin). The Nigerian postgraduate medical journal 38.5 28 Validation of Modified Albumin-Bilirubin-Tumor Stage as a Prognostic Model in Early-Stage Hepatocellular Carcinoma Treated With Radiofrequency Ablation. The Kaohsiung journal of medical sciences 70.5 29 A 17-cm ileocecal inflammatory myofibroblastic tumor with severe inflammatory syndrome in a child: a case report. Journal of surgical case reports 45.5 30 Giant Lipoma of the Thoracic Wall in a Two-Year-Old Girl: Imaging Features Supporting a Benign Diagnosis. Cureus 57.5 31 Retrospective Study of Implementation and Outcomes of a Non-Cryopreserved Autologous Hematopoietic Stem Cell Transplantation Program for Patients With Hematologic Malignancy in a Resource-Limited Center in Chile. Annals of transplantation 69.1 32 Children of advanced cancer patients need better support: A case report. Palliative & supportive care 49.5
PATIENT-FRIENDLY SUMMARY

Association between medical comorbidities at diagnosis and paediatric acute lymphoblastic leukaemia and lymphoblastic lymphoma outcomes: protocol for a systematic review.

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