← Back to all signals
RESEARCH PAPER ANALYSIS

Nomogram Incorporating Inflammatory Index, Pathology, and Molecular Classification for Predicting Recurrence in Patients with Stage I-III Endometrial Cancer: A Multi-Institutional Study.

AI interpretation is pending for this paper.

Open original publication →
PMID40792225
JournalJournal of inflammation research
Publication Date2025-08-06
Ingested2026-08-02 12:03 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

BACKGROUND: This study evaluated the prognostic value of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score for postoperative recurrence in endometrial cancer patients. A nomogram was developed based on clinicopathological parameters, HALP score, and immunohistochemical markers to predict recurrence-free survival (RFS) in patients with stage I-III endometrial cancer. METHODS: This retrospective study included 1,083 patients who underwent hysterectomy at the First Affiliated Hospital of Chongqing Medical University from January 2013 to January 2021. Independent risk factors for RFS were identified using univariate and multivariate Cox regression analyses, and a nomogram was established. External validation was performed with data from Zhujiang Hospital of Southern Medical University and Women and Children's Hospital of Chongqing Medical University (n = 677). RESULTS: Among the entire cohort, 241 cases (13.7%) of endometrial cancer experienced recurrence post-hysterectomy. The median RFS time was 47.0 (range: 6.0-91.0) months. Eleven independent prognostic factors were identified, including age, FIGO staging, histologic type, myometrial invasion, lymphovascular space invasion, Ca125, Ki-67 expression, ER expression, molecular classification, adjuvant therapy, and HALP score, and then a nomogram for predicting recurrence of endometrial cancer was established. The nomogram demonstrated improved predictive accuracy, categorizing patients into high- and low-risk groups. High-risk patients receiving adjuvant treatment had better outcomes than those who did not. CONCLUSION: We developed and validated a nomogram to predict recurrence in endometrial cancer patients. Integrating the HALP score can help clinicians identify high-risk patients and tailor personalized treatment strategies.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 The Hidden Culprit - Caroli Disease Presenting as Recurrent Liver Abscesses in a 5-year-old Boy. International journal of applied & basic medical research 59.6 2 Anti-N-methyl-D-Aspartate Receptor Autoimmune Encephalitis Due to Ovarian Teratoma in a 17-Year-Old Young Woman: Case Report and Review of the Literature. EJIFCC 51.5 3 The Case of Negative Low Density Lipoprotein Cholesterol. EJIFCC 56.0 4 Pediatric venous thromboembolism: an illustrated review. Research and practice in thrombosis and haemostasis 57.6 5 Endoscopic third ventriculostomy for obstructive hydrocephalus combined with biopsy for tumors located in the tectum/posterior third ventricle using a single burr hole technique guided by electromagnetic navigation in pediatric neurosurgery. Clinical neurology and neurosurgery 62.9 6 Paratesticular myofibroblastic lesion in a prepubertal child: a case report of a rare spindle cell tumor with testis-sparing management. Frontiers in urology 47.5 7 Lived experiences of sexual wellbeing and psychosexual needs among adolescents and young adults with sarcoma: a qualitative study. Frontiers in psychology 57.5 8 Prognostic impact of CD123 overexpression on the outcome of pediatric acute myeloid leukemia. Frontiers in oncology 76.4 9 A rare case of multi-segmental lumbar intradural ependymoma: clinical presentation and surgical management: a case report. Frontiers in oncology 58.2 10 Willingness to receive cross-border human papillomavirus vaccination among Chinese male university students: a cross-sectional study with statistical indirect-association analysis. Frontiers in public health 70.0 11 The lived experience of resilience in families of children with cancer: a meta-aggregative synthesis of qualitative studies. Frontiers in psychiatry 73.5 12 Pediatric Leydig Cell Tumor: Biochemical Mimicry of Adrenal Disease and a Cause of Central Precocious Puberty. Acta medica portuguesa 47.5 13 Patterns of Cancer Frequency in Balochistan: Regional Perspectives and Implications for Cancer Control. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 64.5 14 Immunohistochemical Expression of Fascin-1 in Colorectal Carcinoma and Its Association with Pathological Grade and Stage. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 62.0 15 Sinonasal osteosarcoma of the ethmoid bone with decade-later recurrence presenting as early orbital apex syndrome: an 18-year case report. International journal of surgery case reports 55.9 16 Renal cell carcinoma in a child presenting with chronic gross hematuria: A rare case report with diagnostic and surgical insights. Urology case reports 52.3 17 Nasopharyngeal carcinoma with osseous metastases in an 8-year-old girl: a case report. International journal of surgery case reports 57.3 18 Childhood cancer survivors in India: gender gap in long-term survivorship care. The Lancet regional health. Southeast Asia 47.5 19 Extraneural cysticercosis mimicking soft-tissue tumors: a case report from a low-resource setting. International journal of surgery case reports 53.0 20 Delayed Diagnosis of Tuberous Sclerosis Complex Presenting as Abnormal Uterine Bleeding: A Case Report and Literature Review. Clinical case reports 47.5 21 Comparison of diagnostic criteria for disseminated intravascular coagulation in critically ill children. Pediatric research 57.5 22 Age as a core disease modifier: Distinct clinical, molecular and prognostic landscapes of essential thrombocythaemia in adolescents and young adults. British journal of haematology 69.7 23 Global burden of thyroid cancer among women aged 15 to 49 years, 1990-2021: An ecological analysis of spatiotemporal trends, socioeconomic inequalities, and projections to 2040. Medicine 59.9 24 Global trends in gastric cancer burden among adolescents and young adults: A population-based observational study using GBD 2021 data. Medicine 59.0 25 Pathological lead points in pediatric secondary intussusception: A single-center retrospective observational study of five common etiologies. Medicine 65.5 26 Comparative outcomes of phenol therapy and Karydakis flap in pilonidal sinus disease: A retrospective cohort study with 1-year follow-up. Medicine 72.64 27 Non-ossifying fibroma of the proximal tibia mimicking chronic osteomyelitis in a child. BMJ case reports 56.4 28 Optimising Human Papillomavirus Vaccination Strategies for Faster Cervical Cancer Elimination. Acta paediatrica (Oslo, Norway : 1992) 59.2 29 Fighting a Dual Battle: The Harrowing Course of B/T Lineage Mixed Phenotype Acute Leukemia in a Child. Indian journal of pediatrics 28.5 30 Large Estrogen and Cortisol Co-Secreting Adrenocortical Tumor in a 17-year-old Female: Case Report and Literature Review. Hormone research in paediatrics 51.1 31 INTRATHYROIDAL ECTOPIC THYMUS: THE TRICK OF THE TRADE. Hormone research in paediatrics 60.5 32 Dinutuximab beta with TEMIRI chemotherapy in relapsed/refractory neuroblastoma: Real-world insights into the open question of GD2 expression. Translational oncology 75.5
PATIENT-FRIENDLY SUMMARY

Nomogram Incorporating Inflammatory Index, Pathology, and Molecular Classification for Predicting Recurrence in Patients with Stage I-III Endometrial Cancer: A Multi-Institutional Study.

For education only—not personal medical advice.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic