← Back to all signals
RESEARCH PAPER ANALYSIS

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio-Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse.

AI interpretation is pending for this paper.

Open original publication →
PMID41518036
JournalPediatric blood & cancer
Publication Date2026-01-10
Ingested2026-08-02 12:06 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

INTRODUCTION: Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available. Novel therapeutic approaches, such as intraventricular radio-immunotherapy with 131I-omburtamab (Omb), have been developed. In this study, we report a retrospective, single-tertiary center analysis of a 23-year cohort of NB patients with CNS metastases, highlighting current treatment strategies. PATIENTS AND METHODS: Retrospective data analysis of all NB patients with CNS metastases treated at Hospital Sant Joan de Déu, Barcelona, from January 2000 to January 2023. Patient characteristics at diagnosis, first-line treatment, relapse patterns, and CNS metastasis management were analyzed in search of risk variables and survival outcomes. RESULTS: CNS metastases at relapse were identified in 39/185 (21.1%) patients. Median age at diagnosis was 2.7 years, and 24/39 were male. Stage 4 NB with multisite compartment metastases accounted for most cases (92.2%). CNS events occurred predominantly at first relapse (29/39, 74.4%) and with neurological symptoms (23/38, 60.5%). MCYN amplification and concomitant extra-CNS metastases at CNS relapse were associated with poorer overall survival (OS) (p = 0.018 and p = 0.0059, respectively). Neurological symptoms upon relapse significantly increased the risk for subsequent CNS events (p = 0.028). Curative-intent treatment was attempted in 34/39 (87.2%) patients. After adjusting for immortal time bias, RT plus Omb significantly improved OS (p < 0.0001). CONCLUSIONS: In our experience, MYCN amplification and concomitant extra-CNS metastases at CNS relapse significantly decrease OS. Multimodal treatment, including 131I-omburtamab radioimmunotherapy, significantly improves survival outcomes.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 A Rare t(1;11)(q42;q23) Rearrangement with Trisomy 8 and Trisomy 21 in a Pediatric Acute Myeloid Leukemia Patient with Aberrant CD7 Expression and Jacob Syndrome: Diagnostic Value of Conventional Cytogenetics and Fluorescence in Situ Hybridization in a Rapidly Fatal Case. Journal of the Association of Genetic Technologists 56.0 2 A Highly Abnormal Clone in a Pediatric Patient with B-Lymphoblastic Leukemia. Journal of the Association of Genetic Technologists 47.5 3 Maternal polycystic ovary syndrome and the risk of neurodevelopmental disorders in preterm neonates. Pediatric endocrinology, diabetes, and metabolism 65.5 4 [Clinical analysis of 3 cases of childhood primary pure erythroid leukemia and literature review]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 64.4 5 [A retrospective analysis of clinicopathological features and efficacy in 51 patients with high-grade B-cell lymphoma with 11q abnormalities]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 72.1 6 [RET fusion-driven papillary thyroid cancer in children and adolescents: clinical characteristics, molecular mechanisms, and therapeutic advances]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 52.09 7 The diagnostic value of cyclin d1, EGFR, P53 and Ki-67 in epithelial dysplasi of the gallbladder. JPMA. The Journal of the Pakistan Medical Association 60.0 8 Increased brain cancer risk from constant mobile phone use in children. JPMA. The Journal of the Pakistan Medical Association 47.5 9 Pediatric Scurvy Presenting With Vertebral Insufficiency Fractures Mimicking Chronic Recurrent Multifocal Osteomyelitis in a Child With Autism Spectrum Disorder. Cureus 58.4 10 Behind the Curtain: A Pediatric Dermoid Tumor Masquerading as Craniopharyngioma. Cureus 56.0 11 Case Report: novel mutations in SMARCA4 cause Coffin-Siris syndrome type 4 with autism spectrum disorder without visual impairment in one patient. Frontiers in genetics 71.5 12 [Clinicopathological analysis of 18 cases of ovarian juvenile granulosa cell tumor]. Zhonghua fu chan ke za zhi 65.3 13 Efficacy and Safety of CAR-T Cell Therapy in Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia With Central Nervous System Involvement. Cancer medicine 76.66 14 Endothelial and Vascular Toxicity Signals Associated With Doxorubicin: A Pharmacovigilance Analysis of the FDA Adverse Event Reporting System (FAERS) Database. Pharmacoepidemiology and drug safety 67.34 15 Pediatric patients with cancer exhibit increased neutrophil extracellular traps and reduced active deoxyribonuclease I: diagnostic, prognostic, and therapeutic opportunities. Clinical and experimental pediatrics 73.44 16 Hepatocellular Carcinoma at a Center of Clinical Excellence in Colombia: A Real-World Cohort Study of Clinical Characteristics, Treatment Trajectories, and Survival. Journal of hepatocellular carcinoma 71.86 17 [Hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion in a childhood cancer survivor ‒ The role of oral urea in treatment]. Nutricion hospitalaria 59.54 18 NRF2 activation is required for chemotherapy resistance acquisition in medulloblastoma via metabolic and redox adaptation. Redox biology 62.94 19 Oncofertility care evaluation of 599 children and adolescents with cancer and a high risk of treatment-induced gonadal damage: a national paediatric oncology cohort study. Human reproduction (Oxford, England) 78.64 20 Epithelioid hemangioma from inferior turbinate in a pediatric patient: a case report. Journal of surgical case reports 45.5 21 Occupational Therapy Interventions for Pediatric Cancer: A Systematic Review and Meta-Analysis. Physical & occupational therapy in pediatrics 82.84 22 Ovarian Teratoma After Treatment for Coexisting Anti-NMDA Receptor and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Encephalitis. Journal of child neurology 63.8 23 Insight into the Development of Desirable Dosage Forms and Bioenabling Strategies to Improve the Food Effect of Anticancer Drugs for the Pediatric Population. Molecular pharmaceutics 61.76 24 Evaluation of a Rapid Immunoassay for Molecular Subphenotype Classification in Pediatric Acute Cardiorespiratory Failure. Critical care medicine 69.6 25 "A dicey situation:" asymptomatic hypertensive urgency caused by DICER1 mutation-derived cystic nephroma in a 12-month-old. Pediatric nephrology (Berlin, Germany) 56.4 26 Distinct molecular profiles of indeterminate and malignant thyroid nodules in patients under 21 years of age. Endocrine-related cancer 64.5 27 Pediatric Myocarditis: Contemporary Insights Into Viral and Immune-Mediated Pathobiology, Precision Diagnostics, Advanced Multimodality Imaging, Risk Stratification, and Evolving Therapeutic Strategies. Cardiology in review 75.0 28 Clinical characteristics, prognosis, and achievement of transplant in adolescents and adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in Argentina. Hematology, transfusion and cell therapy 71.8 29 "Like a Clinical Nurse Consultant in Your Pocket"-Parents' and Health Care Providers' Perceptions of a Co-Designed Smartphone App Following Treatment for Pediatric Cancer: Mixed Methods Evaluation Study. JMIR cancer 61.94 30 Management of Clostridioides difficile infections in patients with hematological malignancies - a survey by European Conference on Infections in Leukemia (ECIL) and Infectious Diseases Working Party (IDWP) of The European Society for Blood and Marrow Transplantation (EBMT). International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 63.6 31 Polycyclic aromatic hydrocarbon (PAH) levels in indoor air and their associated health risks for children across Europe. Environmental research 57.5 32 Utility and applications of high-field 1.5 T intraoperative magnetic resonance imaging in paediatric neurosurgery: a review of 5 years' experience. Neurocirugia 59.5
PATIENT-FRIENDLY SUMMARY

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio-Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse.

For education only—not personal medical advice.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic